Literature DB >> 7423542

Pharmacokinetics of vinyl chloride in the Rhesus monkey.

A Buchter, J G Filser, H Peter, H M Bolt.   

Abstract

The metabolic elimination of vinyl chloride in Rhesus monkeys is a dose-dependent, satruable process, as in rats. Below 200-300 ppm of vinyl chloride (VC) in atmosphere, elimination obeys a first-order law; the clearance rate is much closer to that found in man than the values for rats, mice and gerbils. The maximal velocity of metabolic elimination of VC at high concentrations in Rhesus monkeys is only about half that of rats when related to kg body weight. It s suggested that Rhesus monkeys mimic the quantitative aspects of VC metabolism better than rats or mice.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 7423542     DOI： 10.1016/0378-4274(80)90099-5

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  6 in total

Review 1.  The closed chamber technique--uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors.

Authors:  J G Filser
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

2. 

Authors: 
Journal:  Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz       Date:  2021-12       Impact factor: 1.513

3.  Inhalation pharmacokinetics based on gas uptake studies. I. Improvement of kinetic models.

Authors:  J G Filser; H M Bolt
Journal:  Arch Toxicol       Date:  1981-07       Impact factor: 5.153

4.  Incorporation of biological information in cancer risk assessment: example--vinyl chloride.

Authors:  C W Chen; J N Blancato
Journal:  Cell Biol Toxicol       Date:  1989-12       Impact factor: 6.691

5.  Inhalation pharmacokinetics based on gas uptake studies. III. A pharmacokinetic assessment in man of "peak concentrations" of vinyl chloride.

Authors:  H M Bolt; J G Filser; A Buchter
Journal:  Arch Toxicol       Date:  1981-11       Impact factor: 5.153

6.  Relevance of experimental studies to human risk.

Authors:  F K Dietz; J C Ramsey; P G Watanabe
Journal:  Environ Health Perspect       Date:  1983-10       Impact factor: 9.031
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.