| Literature DB >> 7422903 |
H R Morris, G W Taylor, J Rokach, Y Girard, P J Piper, J R Tippins, M N Samhoun.
Abstract
We have recently described the structure elucidation of slow reacting substance of anaphylaxis S(SRS-A) from lung and of a slow reacting substance (SRS) from basophilic leukaemia cells as 5-hydroxy-6-cysteinylglycinyl-7,9,11,14-eicosatetraenoic acid. The stereochemistry of this molecule has now been shown to be 5(S)-hydroxy- 6(R)-cysteinylghlycinyl-7,9-trans-11,14-ciseicosatetraenoic acid by comparison of the synthetic and natural products and their derivatives using mass spectrometric and HPLC chromatographic techniques. The synthetic and natural compounds are also indistinguishable by their pharmacological properties, their conversion by soybean lipoxygenase, and their UV spectra.Entities:
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Year: 1980 PMID： 7422903 DOI： 10.1016/0090-6980(80)90047-7
Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980