Literature DB >> 742214

[On a case of a repidly proceeding lethal intoxication due to n-propylajmalium bitartrate (author's transl].

H F Brettel, K Schmidt, U Koch.   

Abstract

A case of N-Propylajmalinum bitartrate intoxication (Neo-Gilurytmal) is reported in which the death occurred within 20 minutes after the consumption of the drug. The quantitative estimation of the drug after isolation using Extrelut--columns was carried out in stomach spectrometrically, in the blood, bile, liver, kidney, and brain by gaschromatography after trifluoroacetylation. A high Prajmalium-bitartrate concentration was found in the blood (3,85 mg/l), negative results in bile and brain, low levels in liver (0,29 mg/kg wet weight) and kidney (0,06 mg/kg wet weight). Prajmalium-bitartrate was ingested together with beer, and a blood alcohol concentration of 0.061% was determined. Furthermore, a quantity corresponding to six tablets of Neo-Gilurytmal was still found in the stomach. The rapid fatal progress of the intoxication is explained as a strong effect of the drug on the heart due to the alcohol accelerated resorption of the substance.

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Year:  1978        PMID: 742214     DOI: 10.1007/bf02092340

Source DB:  PubMed          Journal:  Z Rechtsmed        ISSN: 0044-3433


  7 in total

1.  USE OF THIN LAYER CHROMATOGRAPHY IN THE DIAGNOSIS OF POISONING.

Authors:  I SUNSHINE
Journal:  Am J Clin Pathol       Date:  1963-12       Impact factor: 2.493

2.  [Pharmacokinetic studies with radioactive labeled N-(n-propyl)-ajmaline-hydrogentartrate].

Authors:  E Schaumlöffel
Journal:  Med Welt       Date:  1974-11-29

3.  [Clinical and experimental studies on the effects and duration of action of N-n-propyl-ajmalinium-hydrogentartrate in cardiac arrhythmia].

Authors:  R Koch
Journal:  Arzneimittelforschung       Date:  1972-12

4.  [Suicide attempt with ajmalin].

Authors:  W Hager; K H Friedrich; K Wink; R Wegenhaupt
Journal:  Dtsch Med Wochenschr       Date:  1968-09-20       Impact factor: 0.628

5.  [Oral Gilurytmal poisoning of an adult woman].

Authors:  F J Müller
Journal:  Med Klin       Date:  1969-08-01

6.  [Comparative experimental studies on intoxications with ajmaline and N-n-propyl-ajmalinium-hydrogentartrate (NPAB)].

Authors:  A Weidner; G von Philipsborn
Journal:  Arzneimittelforschung       Date:  1971-05

7.  Suicide by an overdosage of N-propylajmalinium bitartrate.

Authors:  H P Gelbke; H J Schlicht
Journal:  Arch Toxicol       Date:  1977-06-18       Impact factor: 5.153

  7 in total

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