Literature DB >> 7422060

Action of barbiturates on activity of acetylcholinesterase from synaptosomal membranes.

A Pastuszko.   

Abstract

The acetylcholinesterase from synaptosomal membranes is inhibited by anesthetics: Nembutal, brietal, and thiopental. Nembutal and brietal decrease the Km for acetylthiocholine, without changes in Vmas. A noncompetitive type of inhibition is produced by thiopental. This anesthetic decreases Arrhenius plot discontinuity by about 4 degrees C and increases activation energies. Nembutal and brietal do not change Arrhenius plot discontinuities, but they increase activation energies. These results suggest that barbiturates change lipid-protein interactions in synaptosomal membranes.

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Year:  1980        PMID： 7422060     DOI： 10.1007/bf00964714

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  24 in total

1.  Lipid-protein interactions in mitochondria. Changes in mitochondrial adenosine triphosphatase activity induced by n-butyl alcohol.

Authors:  G Lenaz; G Parenti-Castelli; A M Sechi
Journal:  Arch Biochem Biophys       Date:  1975-03       Impact factor: 4.013

2.  SITE OF ACTION OF THIAMYLAL SODIUM ON THE MONOSYNAPTIC SPINAL REFLEX PATHWAY IN CATS.

Authors:  Y LOYNING; T OSHIMA; T YOKOTA
Journal:  J Neurophysiol       Date:  1964-05       Impact factor: 2.714

Review 3.  The influence of temperature-induced phase changes on the kinetics of respiratory and other membrane-associated enzyme systems.

Authors:  J K Raison
Journal:  J Bioenerg       Date:  1973-01

4.  Effect of barbiturates on 'quantal' synaptic transmission in spinal motoneurones.

Authors:  J N Weakly
Journal:  J Physiol       Date:  1969-09       Impact factor: 5.182

5.  The release and molecular state of mammalian brain acetylcholinesterase.

Authors:  E G Hollunger; B H Niklasson
Journal:  J Neurochem       Date:  1973-03       Impact factor: 5.372

6.  Acetylcholinesterase interaction with a lipoprotein matrix.

Authors:  M A Grafius; H E Bond; D B Millar
Journal:  Eur J Biochem       Date:  1971-10-14

7.  Kinetic and thermodynamic aspects of the mechanism of general anesthesia in a model system of firefly luminescence in vitro.

Authors:  I Ueda; H Kamaya
Journal:  Anesthesiology       Date:  1973-05       Impact factor: 7.892

8.  Temperature dependence of anesthetic effects on succinate oxidase activity in uncoupled submitochondrial particles.

Authors:  G Vanderkooi; B Chazotte; R Biethman
Journal:  FEBS Lett       Date:  1978-06-01       Impact factor: 4.124

9.  Differential membrane effects of general and local anesthetics.

Authors:  B I Diamond; H S Havdala; H C Sabelli
Journal:  Anesthesiology       Date:  1975-12       Impact factor: 7.892

10.  Interaction of general anesthetics with phospholipid vesicles and biological membranes.

Authors:  J M Vanderkooi; R Landesberg; H Selick; G G McDonald
Journal:  Biochim Biophys Acta       Date:  1977-01-04
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  2 in total

1.  Differential effect of anionic and cationic drugs on the synaptosome-associated acetylcholinesterase activity of dog brain.

Authors:  G Deliconstantinos; S Tsakiris
Journal:  Biochem J       Date:  1985-07-01       Impact factor: 3.857

2.  Phenobarbital modulates the (Na+, K+)-stimulated ATPase and Ca2+-stimulated ATPase activities by increasing the bilayer fluidity of dog brain synaptosomal plasma membranes.

Authors:  G Deliconstantinos
Journal:  Neurochem Res       Date:  1983-09       Impact factor: 3.996
  2 in total

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