Literature DB >> 7421719

Prediction of response to antihypertensive therapy with prazosin.

E P MacCarthy, G W Frost, J C Monaghan, B A Mennie, G S Stokes.   

Abstract

Blood-pressure responses and changes in plasma drug concentration were studied in 11 hypertensive patients after an initial oral dose of 2 mg of prazosin. Subsequently, blood pressure was monitored during long-term treatment with prazosin. The prazosin reactivity index, a value derived during the first-dose study, appeared to predict the long-term antihypertensive effect of prazosin alone or prazosin combined with bendrofluazide.

Entities:  

Mesh:

Substances:

Year:  1980        PMID: 7421719

Source DB:  PubMed          Journal:  Med J Aust        ISSN: 0025-729X            Impact factor:   7.738


  3 in total

Review 1.  Pharmacokinetic-pharmacodynamic relationships of alpha-adrenoceptor antagonists.

Authors:  R Donnelly; P A Meredith; H L Elliott
Journal:  Clin Pharmacokinet       Date:  1989-10       Impact factor: 6.447

2.  The effect of a single oral dose of prazosin on venous reflex response, blood pressure and pulse rate in normal volunteers.

Authors:  G J Schapel; W H Betts
Journal:  Br J Clin Pharmacol       Date:  1981-12       Impact factor: 4.335

3.  Concentration-effect relationships and individual responses to doxazosin in essential hypertension.

Authors:  R Donnelly; H L Elliott; P A Meredith; J L Reid
Journal:  Br J Clin Pharmacol       Date:  1989-11       Impact factor: 4.335

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.