Literature DB >> 7421150

A fatal overdose with colchicine.

Y H Caplan, K G Orloff, B C Thompson.   

Abstract

A colchicine blood concentration 250 microgram/L was determined in a 39-year-old white female 2 hours following the ingestion of an oral overdose of the drug. At death, 40 hours following ingestion, no drug was detected. Colchicine was extracted from buffered blood using dichloromethane. The evaporated extract was redissolved in 0.1 N HCl and analyzed using a high performance liquid chromatograph equipped with an octadecylsilane reversed phase column.

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Year:  1980        PMID: 7421150     DOI: 10.1093/jat/4.3.153

Source DB:  PubMed          Journal:  J Anal Toxicol        ISSN: 0146-4760            Impact factor:   3.367


  3 in total

1.  Pharmacokinetics and absolute bioavailability of colchicine after i.v. and oral administration in healthy human volunteers and elderly subjects.

Authors:  M Rochdi; A Sabouraud; C Girre; R Venet; J M Scherrmann
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

2.  [Fatal colchicine poisoning].

Authors:  K Harzer
Journal:  Z Rechtsmed       Date:  1984

3.  Detection of colchicine by means of LC-MS/MS after mistaking meadow saffron for bear's garlic.

Authors:  Frank Wehner; Frank Mußhoff; Martin M Schulz; David D Martin; Heinz-Dieter Wehner
Journal:  Forensic Sci Med Pathol       Date:  2006-09       Impact factor: 2.456

  3 in total

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