Literature DB >> 7420358

Synthesis, absorption, and toxicity of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator.

R J Bergeron, P S Burton, K A McGovern, E J St Onge, R R Streiff.   

Abstract

A synthesis of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator, is developed employing N4-benzylspermidine as the starting material. Both the toxicity and the absorption properties of this compound are evaluated, further supporting its potential as a clinical iron chelator.

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Year:  1980        PMID： 7420358     DOI： 10.1021/jm00184a013

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

1.  Bacteriostatic and fungostatic action of catecholamide iron chelators.

Authors:  R J Bergeron; G T Elliott; S J Kline; R Ramphal; L St James
Journal:  Antimicrob Agents Chemother       Date:  1983-11       Impact factor: 5.191

2.  Carvacrol codrugs: a new approach in the antimicrobial plan.

Authors:  Ivana Cacciatore; Mara Di Giulio; Erika Fornasari; Antonio Di Stefano; Laura Serafina Cerasa; Lisa Marinelli; Hasan Turkez; Emanuela Di Campli; Soraya Di Bartolomeo; Iole Robuffo; Luigina Cellini
Journal:  PLoS One       Date:  2015-04-10       Impact factor: 3.240

3.  Solid-Phase Synthesis of Selectively Mono-Fluorobenz(o)ylated Polyamines as a Basis for the Development of 18F-Labeled Radiotracers.

Authors:  Robert Wodtke; Jens Pietzsch; Reik Löser
Journal:  Molecules       Date:  2021-11-20       Impact factor: 4.411
  3 in total

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