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Literature DB >> 7420271

An experimental assessment of the Wagner-Sedman extraction theory for the intestinal absorption of antibacterial sulfonamides.

J M Plá-Delfina, J Moreno, P Riera, V Frías, R Obach, A del Pozo.

Abstract

The chromatographic parameters in a reverse-phase partition system and the rat gut in situ absorption rate constants for 18 antibacterial sulfonamides are highly correlated values. The correlation is logarithmic-logistic in nature, being in accordance with the Wagner-Sedman extraction theory for a constant pH value. Parabolic correlations did not satisfactorily fit the experimental data. This behavior, not frequently reported in regard to the intestinal absorption of drugs, is discussed in connection with other apparently contradictory available data.

Entities: Chemical Species

Mesh：

Substances：
Sulfonamides

Year: 1980 PMID： 7420271 DOI： 10.1007/bf01059647

Source DB: PubMed Journal: J Pharmacokinet Biopharm ISSN： 0090-466X

25 in total

1. Shift of pH-absorption curves.

Authors: D Winne
Journal: J Pharmacokinet Biopharm Date: 1977-02

2. Calculation of the gastric absorption rate constants of 5-substituted barbiturated through the Rm values of substituent deltaRm constants in reversed-phase partition chromatography.

Authors: J M Plá-Delfina; J Moreno; J Durán; A Pozo
Journal: J Pharmacokinet Biopharm Date: 1975-04

3. ABSORPTION AND EXCRETION OF DRUGS. XX. SOME PHARMACOKINETIC ASPECTS OF ABSORPTION AND EXCRETION OF SULFONAMIDES. (2). ABSORPTION FROM RAT SMALL INTESTINE.

Authors: T KOIZUMI; T ARITA; K KAKEMI
Journal: Chem Pharm Bull (Tokyo) Date: 1964-04 Impact factor: 1.645

4. A re-evaluation of the importance of partition coefficients in the gastrointestinal absorption of anutrients.

Authors: J B Houston; D G Upshall; J W Bridges
Journal: J Pharmacol Exp Ther Date: 1974-04 Impact factor: 4.030

5. Studies on absorption of drugs. VII. Absorption of isomeric N1-heterocyclic sulfonamides from the rat small intestines and relations between physicochemical property and absorption of unionized sulfonamides.

Authors: K Kitao; K Kubo; T Morishita; N Yata; A Kamada
Journal: Chem Pharm Bull (Tokyo) Date: 1973-11 Impact factor: 1.645

An experimental assessment of the Wagner-Sedman extraction theory for the intestinal absorption of antibacterial sulfonamides.

1. Shift of pH-absorption curves.

2. Calculation of the gastric absorption rate constants of 5-substituted barbiturated through the Rm values of substituent deltaRm constants in reversed-phase partition chromatography.

3. ABSORPTION AND EXCRETION OF DRUGS. XX. SOME PHARMACOKINETIC ASPECTS OF ABSORPTION AND EXCRETION OF SULFONAMIDES. (2). ABSORPTION FROM RAT SMALL INTESTINE.

4. A re-evaluation of the importance of partition coefficients in the gastrointestinal absorption of anutrients.

5. Studies on absorption of drugs. VII. Absorption of isomeric N1-heterocyclic sulfonamides from the rat small intestines and relations between physicochemical property and absorption of unionized sulfonamides.

6. Theoretical model studies of drug absorption and transport in the GI tract. 3.

7. Drug absorption. 3. Effect of membrane storage on the kinetics of drug absorption.

8. On the parabolic relationship between drug potency and hydrophobicity.

9. Absorption and excretion of drugs. XXX. Absorption of barbituric acid derivatives from rat stomach.

10. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations.

1. Studies on the reliability of a bihyperbolic functional absorption model. I. Ring-substituted anilines.

2. Intestinal absorption-partition relationships: a tentative functional nonlinear model.

3. Studies on the reliability of a bihyperbolic functional absorption model. II. Phenylalkylamines.