Literature DB >> 7420078

Taurine selectivity antagonizes L-kynurenine-produced seizures in mice.

I P Lapin.   

Abstract

Taurine in doses of 100 and 200 mg/kg (intraperitoneally) and 2.5 micrograms (into brain ventricles) antagonized clonic seizures produced by L-kynurenine sulfate injected into brain ventricles of SHR adult male albino mice. Seizures produced by another metabolite of tryptophan in the kynurenine pathway, quinolinic acid, were intensified. The convulsant effects of strychnine, pentylenetetrazol and thiosemicarbazide was not modified.

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Year:  1980        PMID： 7420078     DOI： 10.1007/bf01250666

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  8 in total

1.  Taurine in epilepsy.

Authors:  A Barbeau; J Donaldson
Journal:  Lancet       Date:  1973-08-18       Impact factor: 79.321

2.  [Effect of taurine on audiogenic convulsive seizures in rats].

Authors:  A S Batuev; E A Riabinskaia; N V Gudimova
Journal:  Dokl Akad Nauk SSSR       Date:  1979

3.  Effect of tryptophan metabolites on activity of the epileptogenic focus in the frog hippocampus.

Authors:  W A Gusel; I B Mikhailov
Journal:  J Neural Transm       Date:  1980       Impact factor: 3.575

4.  Convulsions and tremor in immature rats after intraperitoneal injection of kynurenine and its metabolites.

Authors:  I P Lapin
Journal:  Pharmacol Res Commun       Date:  1978-01

5.  First clinical experience on the antiepileptic action of taurine.

Authors:  L Bergamini; R Mutani; M Delsedime; L Durelli
Journal:  Eur Neurol       Date:  1974       Impact factor: 1.710

6.  [Therapeutic effects of taurine in epilepsy: a clinical and polyphysiographic study (author's transl)].

Authors:  G F Marchesi; A Quattrini; O Scarpino; R Dellantonio
Journal:  Riv Patol Nerv Ment       Date:  1975 May-Jun

7.  Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice.

Authors:  I P Lapin
Journal:  J Neural Transm       Date:  1978       Impact factor: 3.575

8.  Effects of taurine, glycine and GABA on convulsions produced by strychnine in the rabbit.

Authors:  J C Roches; H R Zumstein; A Fässler; G Scollo-Lavizzari; L Hösli
Journal:  Eur Neurol       Date:  1979       Impact factor: 1.710
  8 in total
  3 in total

1.  Effect of catecholaminergic drugs on quinolinate- and kynurenine-induced seizures in mice.

Authors:  I P Lapin; I V Ryzov
Journal:  J Neural Transm Gen Sect       Date:  1990

2.  Antagonism of kynurenine-induced seizures by picolinic, kynurenic and xanthurenic acids.

Authors:  I P Lapin
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575

3.  Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles.

Authors:  I P Lapin; I B Prakhie; I P Kiseleva
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575
  3 in total

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