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Literature DB >> 7420076

Dopaminergic and non-dopaminergic neurons in substantia nigra: differential response to bromocriptine.

E Scarnati, C Forchetti, G Ciancarelli, C Pacitti, A Agnoli.

Abstract

Bromocriptine reduces the spontaneous firing rate of neurons in the pars compacta of the substantia nigra but does not change the electrical activity of the neurons located in the pars reticulata. On the other hand, bromocriptine induces contralateral circling behaviour in rats with unilateral 6-hydroxydopamine nigral lesion. This increased motor activity follows an initial period of hypomotility. The decrease of the neuronal firing rate in the pars compacta of the substantia nigra coincides with the hypomotility observed in the lesioned rats.

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Year: 1980 PMID： 7420076 DOI： 10.1007/bf01250664

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

19 in total

1. Correlation of behavioural inhibition or excitation produced by bromocriptine with changes in brain catecholamine turnover.

Authors: S R Snider; C Hutt; B Stein; A L Prasad; S Fahn
Journal: J Pharm Pharmacol Date: 1976-07 Impact factor: 3.765

2. Neuronal responses to iontophoretically applied dopamine, glutamate, and GABA of identified dopaminergic cells in the rat substantia nigra after kainic acid-induced destruction of the striatum.

Authors: E Scarnati; C Pacitti
Journal: Exp Brain Res Date: 1982 Impact factor: 1.972

2 in total

Dopaminergic and non-dopaminergic neurons in substantia nigra: differential response to bromocriptine.

1. Correlation of behavioural inhibition or excitation produced by bromocriptine with changes in brain catecholamine turnover.

2. Synaptic mechanisms in the substantia nigra.

3. Bromocriptine and dopamine-receptor stimulation.

4. Effects of bromocriptine on central dopaminergic receptors.

5. Statistical properties of neuronal spike trains in the substantia nigra: cell types and their interactions.

6. 6-Hydroxy-dopamine induced degeneration of central monoamine neurons.

7. Effect of ergot drugs on central catecholamine neurons: evidence for a stimulation of central dopamine neurons.

8. Dopamine"autoreceptors": pharmacological characterization by microiontophoretic single cell recording studies.

9. The rotating rodent: a two component system?

10. Sleep induced by low doses of apomorphine in rats.

Review 1. The motor effects of bromocriptine--a review.

2. Neuronal responses to iontophoretically applied dopamine, glutamate, and GABA of identified dopaminergic cells in the rat substantia nigra after kainic acid-induced destruction of the striatum.