Literature DB >> 7419649

Determination of amitriptyline-N-oxide, amitriptyline and nortriptyline in serum and plasma by high-performance liquid chromatography.

K M Jensen.   

Abstract

A method for the determination of amitriptyline-N-oxide, amitriptyline and nortriptyline in serum and plasma has been developed. After extraction from serum or plasma the drugs were analysed by high-performance liquid chromatography. The detection limit was 10 ng/ml (2 ml serum or plasma actually used). The coefficient of variation for all three compounds was below 10%. Amitriptyline-N-oxide was found in rat plasma after an oral dose (10 mg/kg) of amitriptyline-N-oxide.

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Year:  1980        PMID： 7419649     DOI： 10.1016/s0378-4347(00)81712-0

Source DB:  PubMed          Journal:  J Chromatogr


  2 in total

1.  Assessment of the anticholinergic effects of antidepressants in a single-dose cross-over study of salivation and plasma levels.

Authors:  L Clemmesen; P L Mikkelsen; H Lund; T G Bolwig; O J Rafaelsen
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

2.  Simultaneous determination of nortriptyline hydrochloride and fluphenazine hydrochloride in microgram quantities from low dosage forms by liquid chromatography-UV detection.

Authors:  Safwan Ashour; Nuha Kattan
Journal:  J Pharm Anal       Date:  2012-05-29
  2 in total

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