Literature DB >> 7419273

Cerebrospinal fluid concentrations of metronidazole, tinidazole and ornidazole in rabbits.

A M Jokipii, L Jokipii.   

Abstract

The penetration of metronidazole, tinidazole and ornidazole into the cerebrospinal fluid (CSF) of rabbits was determined using a bioassay based on the antibacterial activity of the drugs. After an intravenous dose of 50 mg, the CSF levels of each drug exceeded previously reported minimum bactericidal concentrations against Bacteriodes fragilis. Low serum levels of each drug, produced by intramuscular administration of low doses, resulted in CSF/serum ratios ranging from 0.63--0.73.

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Year:  1980        PMID： 7419273     DOI： 10.1007/bf01641471

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


  17 in total

1.  Treatment with metronidazole of three patients with serious infections due to Bacteroides fragilis.

Authors:  H R Ingham; G E Rich; J B Selkon; J H Hale; C M Roxby; M J Betty; R W Johnson; P R Uldall
Journal:  J Antimicrob Chemother       Date:  1975-06       Impact factor: 5.790

2.  Letter: Brain abscess.

Authors:  H R Ingham; J B Selkon; S C So; R Weiser
Journal:  Br Med J       Date:  1975-10-04

3.  Evaluation of sucessive collections of cisternal cerebrospinal fluid in rats, rabbits, and cats.

Authors:  P Ylitalo; E R Heikkinen; V V Myllylä
Journal:  Exp Neurol       Date:  1976-02       Impact factor: 5.330

4.  Penetration of the blood brain barrier by metronidazole and tinidazole.

Authors:  A M Jokipii; V V Myllylä; E Hokkanen; L Jokipii
Journal:  J Antimicrob Chemother       Date:  1977-05       Impact factor: 5.790

5.  Letter: Treatment of a brain abscess due to Bacteroides fragilis with metronidazole.

Authors:  R H George; A J Bint
Journal:  J Antimicrob Chemother       Date:  1976-03       Impact factor: 5.790

6.  A Trichomonas species in a mixed microbial meningitis.

Authors:  H Masur; E Hook; D Armstrong
Journal:  JAMA       Date:  1976-10-25       Impact factor: 56.272

7.  Bacteroides fragilis meningitis in a neonate successfully treated with metronidazole.

Authors:  B W Berman; F H King; D S Rubenstein; S S Long
Journal:  J Pediatr       Date:  1978-11       Impact factor: 4.406

8.  Bactericidal activity of metronidazole, tinidazole and ornidazole against Bacteroides fragilis in vitro.

Authors:  L Jokipii; A M Jokipii
Journal:  J Antimicrob Chemother       Date:  1977-11       Impact factor: 5.790

9.  Bacteriological study of otogenic cerebral abscesses: chemotherapeutic role of metronidazole.

Authors:  H R Ingham; J B Slekon; C M Roxby
Journal:  Br Med J       Date:  1977-10-15

10.  Metronidazole therapy of anaerobic bacteremia, meningitis, and brain abscess.

Authors:  J F Warner; R L Perkins; L Cordero
Journal:  Arch Intern Med       Date:  1979-02
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  4 in total

1.  [Penetration of ceftizoxime (FK 749) into the cerebrospinal fluid (author's transl)].

Authors:  B Ruf
Journal:  Infection       Date:  1982       Impact factor: 3.553

Review 2.  Pharmacokinetics of antibacterial agents in the CSF of children and adolescents.

Authors:  Amanda K Sullins; Susan M Abdel-Rahman
Journal:  Paediatr Drugs       Date:  2013-04       Impact factor: 3.022

Review 3.  Tinidazole in anaerobic infections: a review of its antibacterial activity, pharmacological properties and therapeutic efficacy.

Authors:  A A Carmine; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1982-08       Impact factor: 9.546

4.  Comparative evaluation of the 2-methyl-5-nitroimidazole compounds dimetridazole, metronidazole, secnidazole, ornidazole, tinidazole, carnidazole, and panidazole against Bacteroides fragilis and other bacteria of the Bacteroides fragilis group.

Authors:  L Jokipii; A M Jokipii
Journal:  Antimicrob Agents Chemother       Date:  1985-10       Impact factor: 5.191
  4 in total

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