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Literature DB >> 7419246

Neonatal tolerance induction across H-2 mutational disparity: induction and specificity of tolerance.

Abstract

Mutational disparities derived from alleles of the H-2K and H-2D loci vary widely in their ability to induce neonatal tolerance. The more subtle mutations, such as Kbm5 and Kbm8, proved to be excellent tolerogens, but the Kbm3 mutant (M505) turned out to be the poorest tolerogen yet studied of all H-2 alloantigens. By challenging tolerant animals with skin grafts from related mutants, it was found that expression of tolerance was highly specific. Although a minority of tolerant animals failed to discriminate between the Kb, Kbm5 and Kbm8 antigens, they never failed to discern Kb, Kbm1 and Kbm3 as distinctly different alloantigens.

Entities: Gene

Mesh：

Substances：
H-2 Antigens

Year: 1980 PMID： 7419246 DOI： 10.1007/bf01561560

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

19 in total

10. Structural differences between parent and mutant H-2K glycoproteins from two H-2K gene mutants: b6.c-h-2ba (Hzl) and B6-H-2bd (M505).

Authors: J L Brown; S G Nathenson
Journal: J Immunol Date: 1977-01 Impact factor: 5.422

2 in total

1. Liver tissue graft rejection in murine major histocompatibility complex mutants.

Authors: J S Schultz; R DeMott-Friberg; T F Beals
Journal: Immunogenetics Date: 1982 Impact factor: 2.846

2. Analysis of neonatally induced tolerance of H-2 alloantigens. I. Adoptive transfer indicates that tolerance of class I and class II antigens is maintained by distinct mechanisms.

Authors: J W Streilein; R S Gruchalla
Journal: Immunogenetics Date: 1981 Impact factor: 2.846

2 in total

Neonatal tolerance induction across H-2 mutational disparity: induction and specificity of tolerance.

1. Immunogeneic analysis of H-2 mutations. II. Cellular immunity to the H-2DA mutation.

2. Structural differences between parent and variant H-2K glycoproteins from mouse strains carrying H-2 gene mutations.

Review 3. H-2 mutations: their genetics and effect on immune functions.

4. Mixed lymphocyte reaction caused by an H-2D mutation (congenic strains-B10.D2 new-B10.504).

5. Histocompatibility-2 system in wild mice. I. Identification of five new H-2 chromosomes.

6. Inherited histocompatibility changes in progeny of irradiated and unirradiated inbred mice.

7. Studies of H-2 mutations in C57BL/6 and BALB/c mice.

8. The involvement of a suppressor mechanism in neonatally induced allograft tolerance in mice.

9. Immunogenetic analysis of H-2 mutations. V. Serological analysis of mutations H-2da, H-2ra, and H-2ka1.

10. Structural differences between parent and mutant H-2K glycoproteins from two H-2K gene mutants: b6.c-h-2ba (Hzl) and B6-H-2bd (M505).

1. Liver tissue graft rejection in murine major histocompatibility complex mutants.

2. Analysis of neonatally induced tolerance of H-2 alloantigens. I. Adoptive transfer indicates that tolerance of class I and class II antigens is maintained by distinct mechanisms.