Literature DB >> 7418845

Effects of propafenone on TEA-induced action potentials in vascular smooth muscle of canine coronary arteries.

D R Harder, L Belardinelli.   

Abstract

The Ca++-dependent, TEA-induced action potential is blocked by propafenone in a dose-dependent manner. Such results suggests that in coronary arterial smooth muscle one mechanism of action of propafenone is to inhibit Ca++ inward current.

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Year:  1980        PMID： 7418845     DOI： 10.1007/bf01965982

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  Differential effects of adenosine and nitroglycerin on the action potentials of large and small coronary arteries.

Authors:  D R Harder; L Belardinelli; N Sperelakis; R Rubio; R M Berne
Journal:  Circ Res       Date:  1979-02       Impact factor: 17.367

2.  [The effect of some antiarrhythmic drugs on systolic time intervals in normal subjects (author's transl)].

Authors:  G Breithardt; E Jochum; H Kuhn; L Seipel
Journal:  Z Kardiol       Date:  1978-10

3.  Cardiac glycoside stimulation of inward Ca++ current in vascular smooth muscle of canine coronary artery.

Authors:  L Belardinelli; D Harder; N Sperelakis; R Rubio; R M Berne
Journal:  J Pharmacol Exp Ther       Date:  1979-04       Impact factor: 4.030

4.  [Pharmacology of 2'-[2-hydroxy-3-(propylamino)-propoxy]-3-phenylpropiophenone (Propafenone, SA 79)-hydrochloride].

Authors:  H J Hapke; E Prigge
Journal:  Arzneimittelforschung       Date:  1976

5.  [Indications and risks of anti-arrhythmia treatment with propafenone (author's transl)].

Authors:  O A Beck; H Hochrein
Journal:  Dtsch Med Wochenschr       Date:  1978-08-11       Impact factor: 0.628
  5 in total
  4 in total

Review 1.  Propafenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias.

Authors:  D W Harron; R N Brogden
Journal:  Drugs       Date:  1987-12       Impact factor: 9.546

2.  Functional and metabolic effects of propafenone in the rat heart-lung preparation.

Authors:  S Kashimoto; T Oguchi; T Nakamura; T Kumazawa
Journal:  J Anesth       Date:  1991-10       Impact factor: 2.078

3.  Effects of propafenone on 45Ca movements and contractile responses in vascular smooth muscle.

Authors:  R Carrón; F Pérez-Vizcaino; E Delpón; J Tamargo
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

Review 4.  Clinical pharmacokinetics of propafenone.

Authors:  J T Hii; H J Duff; E D Burgess
Journal:  Clin Pharmacokinet       Date:  1991-07       Impact factor: 6.447
  4 in total

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