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Literature DB >> 7418832

The structure of a novel antitumor antibiotic, saframycin A.

T Arai, K Takahashi, S Nakahara, A Kubo.

Abstract

A structure is assigned to saframycin A, a novel antitumor antibiotic from Streptomyces lavendulae No. 314, on the basis of 13C NMR-spectral data.

Entities: Chemical Species

Mesh：

Substances：

Year: 1980 PMID： 7418832 DOI： 10.1007/bf01965946

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

3 in total

1. Mode of action of saframycin A, a novel heterocyclic quinone antibiotic. Inhibition of RNA synthesis in vivo and in vitro.

Authors: K Ishiguro; S Sakiyama; K Takahashi; T Arai
Journal: Biochemistry Date: 1978-06-27 Impact factor: 3.162

2. New antibiotics saframycins A, B, C, D and E.

Authors: T Arai; K Takahashi; A Kubo
Journal: J Antibiot (Tokyo) Date: 1977-11 Impact factor: 2.649

3. Some chemotherapeutic properties of two new antitumor antibiotics, saframycins A and C.

Authors: T Arai; K Takahashi; K Ishiguro; Y Mikami
Journal: Gan Date: 1980-12

3 in total

9 in total

1. PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity.

Authors: J F M Leal; M Martínez-Díez; V García-Hernández; V Moneo; A Domingo; J A Bueren-Calabuig; A Negri; F Gago; M J Guillén-Navarro; P Avilés; C Cuevas; L F García-Fernández; C M Galmarini
Journal: Br J Pharmacol Date: 2010-11 Impact factor: 8.739

Review 2. Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics.

Authors: V H Le; M Inai; R M Williams; T Kan
Journal: Nat Prod Rep Date: 2015-02 Impact factor: 13.423

Review 3. The mechanism of action of quinone antibiotics.

Authors: J W Lown
Journal: Mol Cell Biochem Date: 1983 Impact factor: 3.396

4. Piperazine ring formation by a single-module NRPS and cleavage by an α-KG-dependent nonheme iron dioxygenase in brasiliamide biosynthesis.

Authors: Bochuan Yuan; Dong Liu; Xin Guan; Yunchen Yan; Jianping Zhang; Yiping Zhang; Donghui Yang; Ming Ma; Wenhan Lin
Journal: Appl Microbiol Biotechnol Date: 2020-05-21 Impact factor: 4.813

5. Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743.

Authors: Christopher M Rath; Benjamin Janto; Josh Earl; Azad Ahmed; Fen Z Hu; Luisa Hiller; Meg Dahlgren; Rachael Kreft; Fengan Yu; Jeremy J Wolff; Hye Kyong Kweon; Michael A Christiansen; Kristina Håkansson; Robert M Williams; Garth D Ehrlich; David H Sherman
Journal: ACS Chem Biol Date: 2011-09-20 Impact factor: 5.100

The structure of a novel antitumor antibiotic, saframycin A.

1. Mode of action of saframycin A, a novel heterocyclic quinone antibiotic. Inhibition of RNA synthesis in vivo and in vitro.

2. New antibiotics saframycins A, B, C, D and E.

3. Some chemotherapeutic properties of two new antitumor antibiotics, saframycins A and C.

1. PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity.

Review 2. Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics.

Review 3. The mechanism of action of quinone antibiotics.

4. Piperazine ring formation by a single-module NRPS and cleavage by an α-KG-dependent nonheme iron dioxygenase in brasiliamide biosynthesis.

5. Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743.

6. Naphthyridinomycin, a DNA-reactive antibiotic.

Review 7. Predominately Uncultured Microbes as Sources of Bioactive Agents.

Review 8. Antimicrobial peptides from marine proteobacteria.

Review 9. Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts.