| Literature DB >> 7418805 |
M D Sayed, A Riszk, F M Hammouda, M M El-Missiry, E M Williamson, F J Evans.
Abstract
The irritant and cytotoxic constituents of the latex of Euphorbia paralias L. were separated from the hydrocarbon fraction by means of solvent partition. 3 new ingenane esters were identified from the toxic ether fraction. The major compound was 3-angelyl-20-deoxyingenol and the 2 minor compounds were 3-hexanoyl-20-deoxyingenol and 3-angelyl-ingenol. These compounds were of a similar potency to podophyllin in the inhibition of 3H-thymidine uptake by TLX/5 mouse lymphoma cells. In addition the compounds produced a persistent erythema of the mouse ear in sub-microgram doses.Entities:
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Year: 1980 PMID： 7418805 DOI： 10.1007/bf01976131
Source DB: PubMed Journal: Experientia ISSN： 0014-4754