Literature DB >> 7418804

Unusually strong lipophilicity of 'fat' or 'super' amino-acids, including a new reference value for glycine.

J L Fauchère, K Q Do, P Y Jow, C Hansch.   

Abstract

Lipophilic, steric, electronic, and enzyme resistance characteristics of carboranylalanine, adamantylalanine, neopentylglycine and tert-butylglycine are described. The first 2 amino-acids display lipophilicities 2 orders of magnitude higher than tryptophan.

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Year:  1980        PMID： 7418804     DOI： 10.1007/bf01976129

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  4 in total

1.  Optical enantiomorphs of tertiary leucine.

Authors:  N IZUMIYA; S C FU; S M BIRNBAUM; J P GREENSTEIN
Journal:  J Biol Chem       Date:  1953-11       Impact factor: 5.157

2.  Hormone--receptor interactions: [4-carboranylalanine, 5-leucine]-enkephalin as a structural probe for the opiate receptor.

Authors:  A Eberle; O Leukart; P Schiller; J L Fauchère; R Schwyzer
Journal:  FEBS Lett       Date:  1977-10-15       Impact factor: 4.124

3.  Selective diffusion of neutral amino acids across lipid bilayers.

Authors:  R A Klein; M J Moore; M W Smith
Journal:  Biochim Biophys Acta       Date:  1971-04-13

4.  Hormone-receptor interactions. Carboranylalanine (Car) as a phenylalanine analogue: reactions with chymotrypsin.

Authors:  W Fischli; O Leukart; R Schwyzer
Journal:  Helv Chim Acta       Date:  1977-04-20       Impact factor: 2.164
  4 in total
  4 in total

1.  Lipophilicity of amino acids.

Authors:  H van de Waterbeemd; H Karajiannis; N El Tayar
Journal:  Amino Acids       Date:  1994-06       Impact factor: 3.520

2.  Amino acid side-chain partition energies and distribution of residues in soluble proteins.

Authors:  H R Guy
Journal:  Biophys J       Date:  1985-01       Impact factor: 4.033

3.  Synthesis, chemical and enzymatic hydrolysis, and aqueous solubility of amino acid ester prodrugs of 3-carboranyl thymidine analogs for boron neutron capture therapy of brain tumors.

Authors:  Sherifa Hasabelnaby; Ayman Goudah; Hitesh K Agarwal; Mosaad S M abd Alla; Werner Tjarks
Journal:  Eur J Med Chem       Date:  2012-07-27       Impact factor: 6.514

4.  A unified hydrophobicity scale for multispan membrane proteins.

Authors:  Julia Koehler; Nils Woetzel; René Staritzbichler; Charles R Sanders; Jens Meiler
Journal:  Proteins       Date:  2009-07
  4 in total

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