Literature DB >> 7418788

Inhibition of isolated rat liver RNApolymerases I and II by aminoacridines.

A Zoncheddu, R Accomando, E Calendi, M Orunesu.   

Abstract

9-Aminoacridine and 2 derivatives which contain hydroxyalkylic or aminoalkylic side chains in the 9-position totally inhibit the transcription of calf thymus DNA by rat liver RNA polymerases I and II. This inhibitory action does not always appear to be completely related to the ability of aminoacridines to intercalate into the DNA template.

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Year:  1980        PMID： 7418788     DOI： 10.1007/bf01976093

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  Structural considerations in the interaction of DNA and acridines.

Authors:  L S LERMAN
Journal:  J Mol Biol       Date:  1961-02       Impact factor: 5.469

2.  Isolation and partial characterization of the multiple forms of deoxyribonucleic acid-dependent ribonucleic acid polymerase in the mouse myeloma, MOPC 315.

Authors:  L B Schwartz; V E Sklar; J A Jaehning; R Weinmann; R G Roeder
Journal:  J Biol Chem       Date:  1974-09-25       Impact factor: 5.157

3.  A procedure for the isolation of enzymically active rat-liver nuclei.

Authors:  C C Widnell; J R Tata
Journal:  Biochem J       Date:  1964-08       Impact factor: 3.857

4.  The interaction of aminocridines with nucleic acids.

Authors:  A Blake; A R Peacocke
Journal:  Biopolymers       Date:  1968       Impact factor: 2.505

5.  Specific nucleolar and nucleoplasmic RNA polymerases.

Authors:  R G Roeder; W J Rutter
Journal:  Proc Natl Acad Sci U S A       Date:  1970-03       Impact factor: 11.205

6.  Diacridines: bifunctional intercalators. II. The biological effects of putrescine, sperimidine and spermine diacridines on HeLa cells and on the L-1210 and P-388 leukemia cells.

Authors:  E S Canellakis; R A Bellantone
Journal:  Biochim Biophys Acta       Date:  1976-02-05

7.  Diacridines: bifunctional intercalators. III. Definition of the general site of action.

Authors:  E S Canellakis; V Bono; R A Bellantone; J S Krakow; R M Fico; R A Schulz
Journal:  Biochim Biophys Acta       Date:  1976-02-05

8.  The mechanism of inhibition of bacteriophage T7 RNA synthesis by acridines, diacridines and actinomycin D.

Authors:  A H Sarris; E G Niles; E S Canellakis
Journal:  Biochim Biophys Acta       Date:  1977-01-20

9.  Interactions of some nitro-derivatives of substituted 9-aminoacridine with DNA.

Authors:  J Filipski; B Marczyński; L Sadzińska; G Chalupka; M Chorazy
Journal:  Biochim Biophys Acta       Date:  1977-09-06

10.  The inhibition of ribonucleic acid polymerase by acridines.

Authors:  B H Nicholson; A R Peacocke
Journal:  Biochem J       Date:  1966-07       Impact factor: 3.857
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