Literature DB >> 7418664

Carbamazepine-10,11-epoxide determined by EMIT carbamazepine reagent.

F Monaco, S Piredda.   

Abstract

Carbamazepine-10,11-epoxide (CBZ-OX) was determined in physiological solutions by means of EMIT carbamazepine reagent. It was recognized as 12 to 20% of the total amount, the cross-reaction being higher at lower CBZ-OX concentrations. A correction for CBZ-OX is necessary when one wants to correlate EMIT carbamazepine values with gas-liquid chromatography values. However, this correction is relevant only for body fluids other than plasma, since the unbound fraction of CBZ-OX would greatly influence the ultrafiltrate serum ratios.

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Year:  1980        PMID: 7418664     DOI: 10.1111/j.1528-1157.1980.tb04298.x

Source DB:  PubMed          Journal:  Epilepsia        ISSN: 0013-9580            Impact factor:   5.864


  2 in total

1.  Valproic acid fails to displace phenobarbitone and carbamazepine from plasma protein binding sites in epileptic patients.

Authors:  F Pisani; G Oteri; R Di Perri
Journal:  Br J Clin Pharmacol       Date:  1981-07       Impact factor: 4.335

Review 2.  Clinical pharmacokinetics and pharmacological effects of carbamazepine and carbamazepine-10,11-epoxide. An update.

Authors:  L Bertilsson; T Tomson
Journal:  Clin Pharmacokinet       Date:  1986 May-Jun       Impact factor: 6.447

  2 in total

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