Literature DB >> 7417826

Spontaneously recurrent seizures after intracerebral injections of kainic acid in rat: a possible model of human temporal lobe epilepsy.

M Pisa, P R Sanberg, M E Corcoran, H C Fibiger.   

Abstract

Intrastriatal injection of kainic acid in rats acutely induced repeated episodes of clonic convulsions. Spontaneously recurrent generalized seizures and a potentiation of the convulsant effects of phentylenetetrazol were then observed in most of the injected rats several weeks after surgery. In addition to marked loss of striatial neurons, limbic pathological alterations similar to those found in human temporal lobe epilepsy were observed in the brains of the kainic-acid treated rats. It is proposed that this preparation might serve as an animal model of human temporal lobe epilepsy.

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Year:  1980        PMID： 7417826     DOI： 10.1016/0006-8993(80)90938-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  14 in total

1.  Hyperthermia-induced seizures modify the GABAA and benzodiazepine receptor binding in immature rat brain.

Authors:  M González-Ramírez; S Orozco; H Salgado; A Feria; L Rocha
Journal:  Cell Mol Neurobiol       Date:  2005-09       Impact factor: 5.046

2.  Intracellular electrophysiology of CA1 pyramidal neurones in slices of the kainic acid lesioned hippocampus of the rat.

Authors:  T J Ashwood; B Lancaster; H V Wheal
Journal:  Exp Brain Res       Date:  1986       Impact factor: 1.972

3.  A reassessment of whether cortical motor neurons die following spinal cord injury.

Authors:  Jessica L Nielson; Melissa K Strong; Oswald Steward
Journal:  J Comp Neurol       Date:  2011-10-01       Impact factor: 3.215

Review 4.  Glutamate, GABA, and CNS disease: a review.

Authors:  J E Walker
Journal:  Neurochem Res       Date:  1983-04       Impact factor: 3.996

5.  Classic hippocampal sclerosis and hippocampal-onset epilepsy produced by a single "cryptic" episode of focal hippocampal excitation in awake rats.

Authors:  Braxton A Norwood; Argyle V Bumanglag; Francesco Osculati; Andrea Sbarbati; Pasquina Marzola; Elena Nicolato; Paolo F Fabene; Robert S Sloviter
Journal:  J Comp Neurol       Date:  2010-08-15       Impact factor: 3.215

6.  Acute effects of the neurotoxin kainic acid on neurons of the pigeon basal ganglia. Electrophysiological and light and electron microscopic observations.

Authors:  G K Rieke; D E Bowers
Journal:  Acta Neuropathol       Date:  1982       Impact factor: 17.088

7.  The ketogenic diet suppresses the cathepsin E expression induced by kainic acid in the rat brain.

Authors:  Hyun Jeong Jeong; Hojeong Kim; Yoon-Kyoung Kim; Sang-Kyu Park; Dong-Won Kang; Dojun Yoon
Journal:  Yonsei Med J       Date:  2010-09       Impact factor: 2.759

8.  Minimal latency to hippocampal epileptogenesis and clinical epilepsy after perforant pathway stimulation-induced status epilepticus in awake rats.

Authors:  Argyle V Bumanglag; Robert S Sloviter
Journal:  J Comp Neurol       Date:  2008-10-20       Impact factor: 3.215

9.  Kainic acid seizures in the rat: differential expression of chromogranin A, carboxypeptidase H and peptidylglycine alpha-amidating monooxigenase in subfields of the hippocampal formation.

Authors:  S K Mahata; B Gruber; M Mahata; C Röder; R Fischer-Colbrie; G Sperk
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

Review 10.  The role of the basal ganglia in the control of seizure.

Authors:  J Vuong; Annaelle Devergnas
Journal:  J Neural Transm (Vienna)       Date:  2017-08-01       Impact factor: 3.575
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