Phenaceturic acid, a new urinary metabolite of styrene in the rat.

1. After administration of styrene to rat, phenaceturic acid, a new metabolite, was isolated. After administration of d8-styrene to rat, deuterium-labelled phenaceturic acid was excreted in the urine. 2. Two metabolic pathways are proposed, based on mass spectra of the deuterium-labelled phenaceturic acid. 3. After a single dose of styrene (250 mg/kg), the excreted phenaceturic acid originating from styrene in the urine amounted to 1.4% dose.