| Literature DB >> 741493 |
Abstract
Compression ischemia of the central nervous system (CNS) in heparinized dogs caused areas of diminished cerebral blood flow measured by 14C-antipyrine autoradiography. Intravenous infusion of indomethacin (1.5 or 4.0 mg/kg) approximately 1 hour before ischemia eliminated the circulatory defects. Prophylactic inhibition of prostaglandin synthetase may promote postischemic perfusion of the CNS by preventing vasoconstriction and by anti-hemostatic effects on blood.Entities:
Mesh：
Substances：
Year: 1978 PMID： 741493 DOI： 10.1161/01.str.9.6.591
Source DB: PubMed Journal: Stroke ISSN： 0039-2499 Impact factor: 7.914