Literature DB >> 7414622

Chronic effects of norharman in rats treated with aniline.

A Hagiwara, M Arai, M Hirose, J I Nakanowatari, H Tsuda, N Ito.   

Abstract

The carcinogenic effects of aniline and norharman given alone or in combination were examined in rats. Neoplastic changes including hyperplastic changes of the urinary bladder were not found in all groups. Papillomas of forestomach were observed in 5 rats out of 110 rats. However, this was not significantly different among the groups. Pyelonephritis or chronic nephritis were also seen in all groups. Hematological and blood biochemical analysis did not show any notable difference in the animals treated with aniline and/or norharman.

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Year:  1980        PMID: 7414622     DOI: 10.1016/0378-4274(80)90170-8

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN: 0378-4274            Impact factor:   4.372


  2 in total

1.  A carcinogenic potency database of the standardized results of animal bioassays.

Authors:  L S Gold; C B Sawyer; R Magaw; G M Backman; M de Veciana; R Levinson; N K Hooper; W R Havender; L Bernstein; R Peto
Journal:  Environ Health Perspect       Date:  1984-12       Impact factor: 9.031

2.  Enhancing effects of harman and norharman on induction of preneoplastic and neoplastic kidney lesions in rats initiated with N-ethyl-N-hydroxyethylnitrosamine.

Authors:  A Hagiwara; M Sano; E Asakawa; H Tanaka; R Hasegawa; N Ito
Journal:  Jpn J Cancer Res       Date:  1992-09
  2 in total

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