Literature DB >> 7413999

Studies on the modulation of immunoglobulin production by prostaglandins.

T Morito, A D Bankhurst, R C Williams.   

Abstract

The present study investigated the effect of prostaglandins (PG) on the in vitro production of polyclonal IgG and IgM by pokeweed mitogen- stimulated normal human peripheral mononuclear cells. Concentrations of PGE1 and PGA1 in excess of 10(-6)M were suppressive. PGE2 and PGs of the F series were less effective and significant suppression was seen in concentrations greater than 10(05)M. Indomethacin added to cell cultures did not enhance Ig production. This discrepancy between physiologic PG concentrations and the very large pharmacologic concentration necessary to suppress Ig synthesis in vitro makes the physiologic role of PG in the modulation of Ig synthesis questionable.

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Year:  1980        PMID： 7413999     DOI： 10.1016/s0090-6980(80)80055-4

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  4 in total

Review 1.  Regulation of the immune response by prostaglandins.

Authors:  J S Goodwin; J Ceuppens
Journal:  J Clin Immunol       Date:  1983-10       Impact factor: 8.317

2.  Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon.

Authors:  P Flodgren; H O Sjögren
Journal:  Cancer Immunol Immunother       Date:  1985       Impact factor: 6.968

3.  Regulation of human B cell activation by prostaglandin E2. Suppression of the generation of immunoglobulin-secreting cells.

Authors:  D F Jelinek; P A Thompson; P E Lipsky
Journal:  J Clin Invest       Date:  1985-04       Impact factor: 14.808

4.  Depression of lymphocyte traffic in sheep by anaesthesia and associated changes in efferent-lymph PGE2 and antibody levels.

Authors:  T C Moore; C H Spruck; L E Leduc
Journal:  Immunology       Date:  1988-01       Impact factor: 7.397
  4 in total

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