Reye syndrome: a predictably curable disease.

Seventeen years after the initial description of this syndrome of hepatic failure and encephalopathy, the etiology and pathophysiology are still not well defined. Clinical staging of the disease proposed by Lovejoy and colleagues is helpful and is recommended as a standard to be followed by referring physicians and hospital-based pediatricians and intensivists. A new classification based on the status of intracranial pressure and unrelated to clinical, laboratory, or EEG staging is presented.