Literature DB >> 7411206

Epsilon-aminocaproic acid and recurrent subarachnoid hemorrhage: a clinical trial.

W A Shucart, S K Hussain, P R Cooper.   

Abstract

A clinical trial of epsilon-aminocaproic acid (EACA) in preventing recurrent hemorrhage from intracranial arterial aneurysms is reported. Previous reports were reviewed, and their results concerning antifibrinolytic agents were inconclusive in establishing their efficacy. One hundred patients with documented ruptured intracranial aneurysms were admitted to this study within 48 hours of the initial hemorrhage: 45 patients received 36 gm of EACA/day, with 11 documented rebleeds and one suspected rebleed. No benefit was seen from the use of EACA.

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Year:  1980        PMID: 7411206     DOI: 10.3171/jns.1980.53.1.0028

Source DB:  PubMed          Journal:  J Neurosurg        ISSN: 0022-3085            Impact factor:   5.115


  8 in total

Review 1.  Antifibrinolytic agents in subarachnoid haemorrhage.

Authors:  K W Lindsay
Journal:  J Neurol       Date:  1987-01       Impact factor: 4.849

2.  Benefits and risks of antifibrinolytic therapy in the management of ruptured intracranial aneurysms. A double-blind placebo-controlled study.

Authors:  S A Tsementzis; E R Hitchcock; C H Meyer
Journal:  Acta Neurochir (Wien)       Date:  1990       Impact factor: 2.216

3.  Ruptured intracranial aneurysms: has the incidence of early rebleeding been over-estimated?

Authors:  R S Maurice-Williams
Journal:  J Neurol Neurosurg Psychiatry       Date:  1982-09       Impact factor: 10.154

4.  Fibrinolytic activity after subarachnoid haemorrhage and the effect of tranexamic acid.

Authors:  S A Tsementzis; W P Honan; S Nightingale; E R Hitchcock; C H Meyer
Journal:  Acta Neurochir (Wien)       Date:  1990       Impact factor: 2.216

Review 5.  Antifibrinolytic treatment in subarachnoid haemorrhage: present state.

Authors:  H Fodstad
Journal:  Acta Neurochir (Wien)       Date:  1982       Impact factor: 2.216

6.  Rebleeding, ischaemia and hydrocephalus following anti-fibrinolytic treatment for ruptured cerebral aneurysms: a retrospective clinical study.

Authors:  G Pinna; A Pasqualin; C Vivenza; R Da Pian
Journal:  Acta Neurochir (Wien)       Date:  1988       Impact factor: 2.216

7.  Comparative clinical trial of epsilon amino-caproic acid and tranexamic acid in the prevention of early recurrence of subarachnoid haemorrhage.

Authors:  U M Chowdhary; K Sayed
Journal:  J Neurol Neurosurg Psychiatry       Date:  1981-09       Impact factor: 10.154

Review 8.  Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage.

Authors:  Merih I Baharoglu; Menno R Germans; Gabriel J E Rinkel; Ale Algra; Marinus Vermeulen; Jan van Gijn; Yvo B W E M Roos
Journal:  Cochrane Database Syst Rev       Date:  2013-08-30
  8 in total

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