| Literature DB >> 7409864 |
Abstract
Mouse anti-HLA-A, B monoclonal antibodies have been used to study the homologues of HLA-A, B antigens in other primate species. Immunoprecipitates of primate histocompatibility antigens from extracts of radioactively labeled lymphocytes were analyzed by SDS-polyacrylamide electrophoresis. Primate histocompatibility antigens appear to have similar molecular structure to human HLA antigens. Owl monkeys, which react polymorphically with some monomorphic anti-HLA antibodies, showed biochemical differences which correlated with the serological polymorphism. An antibody (W6/32) which only reacts with the HLA/beta 2-microglobulin complex in humans and not with the free HLA heavy chain has the reverse specificity in some owl monkeys.Entities:
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Year: 1980 PMID: 7409864 DOI: 10.1007/bf01567779
Source DB: PubMed Journal: Immunogenetics ISSN: 0093-7711 Impact factor: 2.846