Literature DB >> 7408914

Puberty in Laron type dwarfism.

Z Laron, R Sarel, A Pertzelan.   

Abstract

The onset and progress of puberty was followed in 18 patients (7 males and 11 females) with Laron-type dwarfism (LTD). The boys had delayed puberty, testicular enlargement occurring between 12--14 years being the first sign. The first conscious ejaculation occurred between 17--21 years and full maturity was reached after the age of 22. In girls menarche occurred between 13--14 years and full maturity was reached between 16-19 years. Two patients--one male and one female--have children.

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Year:  1980        PMID： 7408914     DOI： 10.1007/bf00442408

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  13 in total

Review 1.  Isolated human growth hormone deficiency and related disorders.

Authors:  D Rabinowitz; T J Merimee
Journal:  Isr J Med Sci       Date:  1973 Nov-Dec

2.  Growth and growth hormone. II. A comparison of isolated growth-hormone deficiency and multiple pituitary-hormone deficiencies in 35 patients with idiopathic hypopituitary dwarfism.

Authors:  H G Goodman; M M Grumbach; S L Kaplan
Journal:  N Engl J Med       Date:  1968-01-11       Impact factor: 91.245

3.  An unusual variety of endocrine dwarfism: subresponsiveness to growth hormone in a sexually mature dwarf.

Authors:  T J Merimee; J Hall; D Rabinowitz; V A McKusick; D L Rimoin
Journal:  Lancet       Date:  1968-07-27       Impact factor: 79.321

4.  Administration of growth hormone to patients with familial dwarfism with high plasma immunoreactive growth hormone: measurement of sulfation factor, metabolic and linear growth responses.

Authors:  Z Laron; A Pertzelan; M Karp; A Kowadlo-Silbergeld; W H Daughaday
Journal:  J Clin Endocrinol Metab       Date:  1971-08       Impact factor: 5.958

5.  Pituitary dwarfism with high serum levels of growth hormone.

Authors:  Z Laron; A Pertzelan; M Karp
Journal:  Isr J Med Sci       Date:  1968 Jul-Aug

6.  [The normal testicular volume in Israeli children and adolescents].

Authors:  E Zilka; Z Laron
Journal:  Harefuah       Date:  1969-12-01

7.  Penis and testicular size in patients with growth hormone insufficency.

Authors:  Z Laron; R Sarel
Journal:  Acta Endocrinol (Copenh)       Date:  1970-04

8.  Genetic pituitary dwarfism with high serum concentation of growth hormone--a new inborn error of metabolism?

Authors:  Z Laron; A Pertzelan; S Mannheimer
Journal:  Isr J Med Sci       Date:  1966 Mar-Apr

9.  Testicular size: assessment and clinical importance.

Authors:  A Prader
Journal:  Triangle       Date:  1966

10.  Interrelation of the therapeutic effects of growth hormone and testosterone on growth in hypopituitarism.

Authors:  A Aynsley-Green; M Zachmann; A Prader
Journal:  J Pediatr       Date:  1976-12       Impact factor: 4.406
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  16 in total

Review 1.  Somatomedin-1 (insulin-like growth factor-I) in clinical use. Facts and potential.

Authors:  Z Laron
Journal:  Drugs       Date:  1993-01       Impact factor: 9.546

Review 2.  Growth hormone cotreatment with gonadotropins in ovulation induction.

Authors:  P G Artini; A A de Micheroux; G D'Ambrogio
Journal:  J Endocrinol Invest       Date:  1996-12       Impact factor: 4.256

3.  A Reevaluation of the Question: Is the Pubertal Resurgence in Pulsatile GnRH Release in the Male Rhesus Monkey (Macaca mulatta) Associated With a Gonad-Independent Augmentation of GH Secretion?

Authors:  M Shahab; M Vargas Trujillo; T M Plant
Journal:  Endocrinology       Date:  2015-07-16       Impact factor: 4.736

4.  Testosterone stimulates growth of tibial epiphyseal growth plate and insulin-like growth factor-1 receptor abundance in hypophysectomized and castrated rats.

Authors:  M Phillip; G Maor; S Assa; A Silbergeld; Y Segev
Journal:  Endocrine       Date:  2001-10       Impact factor: 3.633

Review 5.  Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.

Authors:  Edward O List; Lucila Sackmann-Sala; Darlene E Berryman; Kevin Funk; Bruce Kelder; Elahu S Gosney; Shigeru Okada; Juan Ding; Diana Cruz-Topete; John J Kopchick
Journal:  Endocr Rev       Date:  2010-12-01       Impact factor: 19.871

6.  Long-term auxological and pubertal outcome of patients with hereditary insulin-like growth factor-I deficiency (Laron and growth hormone-gene deletion syndrome) treated with recombinant human insulin-like growth factor-I.

Authors:  M F Messina; T Arrigo; M Valenzise; L Ghizzoni; M Caruso-Nicoletti; S Zucchini; P Chiabotto; G Crisafulli; G Zirilli; F De Luca
Journal:  J Endocrinol Invest       Date:  2010-06-11       Impact factor: 4.256

7.  Growth curves for Laron syndrome.

Authors:  Z Laron; P Lilos; B Klinger
Journal:  Arch Dis Child       Date:  1993-06       Impact factor: 3.791

8.  Treatment of pituitary gigantism with the growth hormone receptor antagonist pegvisomant.

Authors:  Naila Goldenberg; Michael S Racine; Pamela Thomas; Bernard Degnan; William Chandler; Ariel Barkan
Journal:  J Clin Endocrinol Metab       Date:  2008-05-20       Impact factor: 5.958

Review 9.  Genomic dissection of the cytokine-controlled STAT5 signaling network in liver.

Authors:  Atsushi Hosui; Lothar Hennighausen
Journal:  Physiol Genomics       Date:  2008-05-06       Impact factor: 3.107

10.  Profile of mecasermin for the long-term treatment of growth failure in children and adolescents with severe primary IGF-1 deficiency.

Authors:  Danilo Fintini; Claudia Brufani; Marco Cappa
Journal:  Ther Clin Risk Manag       Date:  2009-08-03       Impact factor: 2.423
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