Literature DB >> 7407611

Regional distribution of a novel analgesic dipeptide kyotorphin (Tyr-Arg) in the rat brain and spinal cord.

H Ueda, H Shiomi, H Takagi.   

Abstract

Using high performance liquid chromatography, we measured kyotorphin content in discrete regions of the rat brain and spinal cord in an attempt to clarify its physiological significance. Higher concentrations of the dipeptide were found in the midbrain, pons plus medulla oblongata and dorsal cord, which are the most sensitive sites for the microinjection of morphine and/or electrical stimulation-induced analgesia. Kyotorphin may play a physiological role in pain control in the central nervous system.

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Year:  1980        PMID： 7407611     DOI： 10.1016/0006-8993(80)90761-1

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

1.  Kyotorphin transport and metabolism in rat and mouse neonatal astrocytes.

Authors:  Jianming Xiang; Huidi Jiang; Yongjun Hu; David E Smith; Richard F Keep
Journal:  Brain Res       Date:  2010-06-09       Impact factor: 3.252

2.  Dipeptidase activities in rat brain synaptosomes can be distinguished on the basis of inhibition by bestatin and amastatin: identification of a kyotorphin (Tyr-Arg)-degrading enzyme.

Authors:  A T Orawski; W H Simmons
Journal:  Neurochem Res       Date:  1992-08       Impact factor: 3.996

3.  The pH-dependent conformational states of kyotorphin: a constant-pH molecular dynamics study.

Authors:  Miguel Machuqueiro; António M Baptista
Journal:  Biophys J       Date:  2006-12-15       Impact factor: 4.033

4.  Effect of the endogenous analgesic dipeptide, kyotorphin, on transmitter release in sympathetic ganglia.

Authors:  K Hirai; Y Katayama
Journal:  Br J Pharmacol       Date:  1985-07       Impact factor: 8.739

5.  Benzoyl chloride derivatization with liquid chromatography-mass spectrometry for targeted metabolomics of neurochemicals in biological samples.

Authors:  Jenny-Marie T Wong; Paige A Malec; Omar S Mabrouk; Jennifer Ro; Monica Dus; Robert T Kennedy
Journal:  J Chromatogr A       Date:  2016-04-04       Impact factor: 4.601

Review 6.  Pharmacological Potential of the Endogenous Dipeptide Kyotorphin and Selected Derivatives.

Authors:  Juliana Perazzo; Miguel A R B Castanho; Sónia Sá Santos
Journal:  Front Pharmacol       Date:  2017-01-12       Impact factor: 5.810

7.  Neuropeptide Kyotorphin (Tyrosyl-Arginine) has Decreased Levels in the Cerebro-Spinal Fluid of Alzheimer's Disease Patients: Potential Diagnostic and Pharmacological Implications.

Authors:  Sara Matos Santos; Laura Garcia-Nimo; Sónia Sá Santos; Isaura Tavares; José A Cocho; Miguel A R B Castanho
Journal:  Front Aging Neurosci       Date:  2013-10-30       Impact factor: 5.750

8.  The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology.

Authors:  Rita F Belo; Margarida L F Martins; Liana Shvachiy; Tiago Costa-Coelho; Carolina de Almeida-Borlido; João Fonseca-Gomes; Vera Neves; Hugo Vicente Miranda; Tiago F Outeiro; Joana E Coelho; Sara Xapelli; Cláudia A Valente; Montserrat Heras; Eduard Bardaji; Miguel A R B Castanho; Maria José Diógenes; Ana M Sebastião
Journal:  Front Pharmacol       Date:  2020-07-09       Impact factor: 5.810

Review 9.  Review of Kyotorphin Research: A Mysterious Opioid Analgesic Dipeptide and Its Molecular, Physiological, and Pharmacological Characteristics.

Authors:  Hiroshi Ueda
Journal:  Front Med Technol       Date:  2021-04-01
  9 in total

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