Daunorubicin, daunorubicinol and DNA plasma kinetics after I.V. administration of daunorubicin-DNA complex in the rabbit. II. -- Effects of R. E. S.-blockade.

Reticuloendothelial system-blockade induced by collodial carbon in rabbits produced only a single modification of the plasma kinetics of daunorubicin-DNA complex, consisting in a significant prolongation of the distribution phase of the vector (DNA). No changes in distribution and metabolism of the cytostatic drug (DNR) were observed. Thus, a lysosomotropic mechanism does not play a major role in the disposition of DNA-complexed DNR.