A theoretical description of phase diagrams for nonideal lipid mixtures.

A theoretical description of phase diagrams for nonideal lipid mixtures is presented. The phase diagrams in this model are constructed by a quasi-chemical approach for the calculations of enthalpies of the regular solutions and by van der Waals attractive energy of lipids which described the degree of nonideality in the solid and fluid phases. The results of theoretical calculations of phase diagrams for dimyristoyl phsophatidylcholine/dipalmitoyl phosphatidylcholine dimyristoyl phosphatidylcholine/distearoyl phosphatidylcholine, and dipalmitoyl phosphatidylcholine/distearoyl phosphatidylcholine mixtures are in good agreement with experimental data.