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Literature DB >> 7406477

Mechanism of virucidal activity of retinoids: protein removal from bacteriophage phi 6 envelope.

Abstract

The mechanism of the potent virucidal activity of retinol (vitamin A) and retinal (vitamin A aldehyde) was investigated for the interaction of these compounds with a model system enveloped virus, bacteriophage phi 6. The retinoids bind to and inactivate phi 6 without causing large-scale disruption of the virion. Inactivated virions have completely lost the ability to adsorb to host bacteria due to the loss of a viral envelope protein necessary for adsorption.

Entities: Chemical Species

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Year: 1980 PMID： 7406477 PMCID： PMC283925 DOI： 10.1128/AAC.17.6.1034

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

1. Retinoic acid inhibition of Epstein-Barr virus induction.

Authors: N Yamamoto; K Bister; H zur Hausen
Journal: Nature Date: 1979-04-05 Impact factor: 49.962

2. Enveloped virus inactivation by fatty acid derivatives.

Authors: J A Sands; L D Auperin; A Reinhardt
Journal: Antimicrob Agents Chemother Date: 1979-01 Impact factor: 5.191

3. Extreme sensitivity of enveloped viruses, including herpes simplex, to long-chain unsaturated monoglycerides and alcohols.

Authors: J Sands; D Auperin; W Snipes
Journal: Antimicrob Agents Chemother Date: 1979-01 Impact factor: 5.191

4. The induction of differentiation in teratocarcinoma stem cells by retinoic acid.

Authors: S Strickland; V Mahdavi
Journal: Cell Date: 1978-10 Impact factor: 41.582

5. Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion.

Authors: A K Verma; B G Shapas; H M Rice; R K Boutwell
Journal: Cancer Res Date: 1979-02 Impact factor: 12.701

Mechanism of virucidal activity of retinoids: protein removal from bacteriophage phi 6 envelope.

1. Retinoic acid inhibition of Epstein-Barr virus induction.

2. Enveloped virus inactivation by fatty acid derivatives.

3. Extreme sensitivity of enveloped viruses, including herpes simplex, to long-chain unsaturated monoglycerides and alcohols.

4. The induction of differentiation in teratocarcinoma stem cells by retinoic acid.

5. Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion.

6. Bacteriophage phi6: a Lipid-Containing Virus of Pseudomonas phaseolicola.

7. Studies with a hydrophobic, spin-labeled virucidal agent.

8. Proteins of bacteriophage phi6.

9. Virucidal activity of retinal.

10. Inactivation of lipid-containing viruses by long-chain alcohols.

1. Differential modulating effects of retinoic acid on interferon antiviral activity.