Literature DB >> 7405751

The topical anti-inflammatory effects of piroxicam in rodents.

D L Larson, J G Lombardino.   

Abstract

Piroxicam is a structurally novel, long-acting anti-inflammatory drug with potent activity following oral administration in animal models of inflammation and in human inflammatory diseases. The present studies, performed in rats, demostrate that topically applied piroxicam is a potent inhibitor of inflammation induced by either carrageenin or complete Freund's adjuvant. Comparable potencies (ED50 approximately 1--5 mg/kg) were obtained for topically and orally administered piroxicam in these models of inflammation. The potency of topical piroxicam exceeds that of topically applied bufexamac or phenylbutazone in the rat adjuvant arthritis model.

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Year:  1980        PMID： 7405751     DOI： 10.1007/bf02025943

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  15 in total

1.  Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.

Authors:  C A WINTER; E A RISLEY; G W NUSS
Journal:  Proc Soc Exp Biol Med       Date:  1962-12

2.  [THE LOCAL EFFECT OF PHENYLBUTAZONE ON ULTRAVIOLET ERYTHEMA IN MAN].

Authors:  H POZENEL
Journal:  Arzneimittelforschung       Date:  1963-09

3.  Effect of topical administration of antiinflammatory drugs to rats with adjuvant arthritis.

Authors:  R D Heilman; R R Reo
Journal:  Arthritis Rheum       Date:  1975 Sep-Oct

4.  [Precutaneous absorption of anti-inflammatory agents].

Authors:  P Panse; P Zeiller; K H Sensch
Journal:  Arzneimittelforschung       Date:  1974-09

5.  Local anti-inflammatory properties of etoclofene. A new fenamate derivative.

Authors:  G B Fregnan; A L Torsello; S Brunet
Journal:  Pharmacology       Date:  1974       Impact factor: 2.547

6.  Effects of topical hydrocortisone and acetylsalicylic acid on the primary lesion of adjuvant-induced arthritis.

Authors:  D T Walz; M M Dolan; M J DiMartino; S L Yankell; H Friedman
Journal:  Proc Soc Exp Biol Med       Date:  1971-09

7.  Cutaneous thermometry for topical therapy evalaation of U. V. erythema in the guinea-pig.

Authors:  G Lambelin; D Vassart-Thys; J Roba
Journal:  Arzneimittelforschung       Date:  1971-01

8.  [Local antiphlogistic treatment with butazolidine-ointment].

Authors:  G Keller
Journal:  Ther Ggw       Date:  1969-08

9.  Piroxicam, a novel anti-inflammatory agent.

Authors:  E H Wiseman; Y H Chang; J G Lombardino
Journal:  Arzneimittelforschung       Date:  1976

10.  Piroxicam (CP 16171) in rheumatoid arthritis: a controlled clinical trial with novel assessment techniques.

Authors:  M Weintraub; R F Jacox; C D Angevine; E C Atwater
Journal:  J Rheumatol       Date:  1977       Impact factor: 4.666
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  6 in total

1.  Tenidap, a structurally novel drug for the treatment of arthritis: antiinflammatory and analgesic properties.

Authors:  P F Moore; D L Larson; I G Otterness; A Weissman; S B Kadin; F J Sweeney; J D Eskra; A Nagahisa; M Sakakibara; T J Carty
Journal:  Inflamm Res       Date:  1996-02       Impact factor: 4.575

Review 2.  Piroxicam. A reappraisal of its pharmacology and therapeutic efficacy.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1984-10       Impact factor: 9.546

3.  Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream.

Authors:  Muthanna F Abdulkarim; Ghassan Z Abdullah; Mallikarjun Chitneni; Ibrahim M Salman; Omar Z Ameer; Mun F Yam; Elrashid S Mahdi; Munavvar A Sattar; Mahiran Basri; Azmin M Noor
Journal:  Int J Nanomedicine       Date:  2010-11-04

4.  The topical anti-inflammatory and analgesic properties of bromfenac in rodents.

Authors:  J C Nolan; L E Wagner; C E Gathright; D J Stephens; L F Sancilio
Journal:  Agents Actions       Date:  1988-08

Review 5.  Piroxicam: a review of its pharmacological properties and therapeutic efficacy.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1981-09       Impact factor: 9.546

6.  In vitro permeation and in vivo anti-inflammatory and analgesic properties of nanoscaled emulsions containing ibuprofen for topical delivery.

Authors:  Ghassan Z Abdullah; Muthanna F Abdulkarim; Ibrahim M Salman; Omar Z Ameer; Mun F Yam; Ahmed F Mutee; Mallikarjun Chitneni; Elrashid S Mahdi; Mahiran Basri; Munavvar A Sattar; Azmin M Noor
Journal:  Int J Nanomedicine       Date:  2011-02-17
  6 in total

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