Literature DB >> 7404596

Induction of hepatocellular carcinoma in rat liver by initial treatment with benzo(a)pyrene after partial hepatectomy and promotion by phenobarbital.

T Kitagawa, T Hirakawa, T Ishikawa, N Nemoto, S Takayama.   

Abstract

The hepatocarcinogenicity of benzo(a)pyrene(BP) in the rat was examined. Rats were treaated with BP after partial hepatectomy and then kept on a diet containing phenobarbital (PB) as a promoter. Tumors including a hepatocellular carcinoma developed in the rat liver by week 52.

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Year:  1980        PMID： 7404596     DOI： 10.1016/0378-4274(80)90186-1

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  14 in total

Review 1.  Tumor promotion in the liver.

Authors:  R Schulte-Hermann
Journal:  Arch Toxicol       Date:  1985-08       Impact factor: 5.153

2.  Dietary effects on initiation and promotion of hepatocarcinogenesis in rat.

Authors:  S Hendrich; H P Glauert; H C Pitot
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

3.  Absence of H-ras point mutation at codon 12 in N-methyl-N-nitrosourea-induced hepatocellular neoplasms in the rat.

Authors:  H Li; G H Lee; L X Cui; J Liu; K Nomura; K Ohtake; T Kitagawa
Journal:  J Cancer Res Clin Oncol       Date:  1990       Impact factor: 4.553

4.  Effects of benzo[a]pyrene exposure on human hepatocellular carcinoma cell angiogenesis, metastasis, and NF-κB signaling.

Authors:  Qian Ba; Junyang Li; Chao Huang; Hongling Qiu; Jingquan Li; Ruiai Chu; Wei Zhang; Dong Xie; Yongning Wu; Hui Wang
Journal:  Environ Health Perspect       Date:  2014-10-17       Impact factor: 9.031

5.  Chemopreventive effects of beta-carotene, alpha-tocopherol and five naturally occurring antioxidants on initiation of hepatocarcinogenesis by 2-amino-3-methylimidazo[4,5-f]quinoline in the rat.

Authors:  H Tsuda; N Uehara; Y Iwahori; M Asamoto; M Iigo; M Nagao; K Matsumoto; M Ito; I Hirono
Journal:  Jpn J Cancer Res       Date:  1994-12

6.  Formation and persistence of benzo(a)pyrene metabolite-DNA adducts.

Authors:  S J Stowers; M W Anderson
Journal:  Environ Health Perspect       Date:  1985-10       Impact factor: 9.031

7.  Role of tissue exposure and DNA lesions for organ-specific effects of carcinogenic trans-4-acetylaminostilbene in rats.

Authors:  H G Neumann
Journal:  Environ Health Perspect       Date:  1983-03       Impact factor: 9.031

8.  Benzo[a]pyrene-induced metabolic shift from glycolysis to pentose phosphate pathway in the human bladder cancer cell line RT4.

Authors:  Nisha Verma; Mario Pink; Stefan Boland; Albert W Rettenmeier; Simone Schmitz-Spanke
Journal:  Sci Rep       Date:  2017-08-29       Impact factor: 4.379

9.  Synergistic effects of low-dose hepatocarcinogens in induction of glutathione S-transferase P-positive foci in the rat liver.

Authors:  R Hasegawa; M Mutai; K Imaida; H Tsuda; S Yamaguchi; N Ito
Journal:  Jpn J Cancer Res       Date:  1989-10

10.  Decreased levels of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts in rats treated with beta-carotene, alpha-tocopherol and freeze-dried aloe.

Authors:  N Uehara; Y Iwahori; M Asamoto; H Baba-Toriyama; M Iigo; M Ochiai; M Nagao; M Nakayama; M Degawa; K Matsumoto; I Hirono; H Beppu; K Fujita; H Tsuda
Journal:  Jpn J Cancer Res       Date:  1996-04
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