Literature DB >> 7404592

The effects of aluminum on microtubular integrity using in vitro and in vivo models.

D W Bonhaus, K M McCormack, G H Mayor, J C Mattson, J B Hook.   

Abstract

Since neuronal lesions produced by aluminum (Al) are morphologically similar to lesions produced by microtubule inhibitors, the effect of aluminum on microtubule integrity was investigated. Aluminum inhibited microtubule formation at concentrations as low as 0.1 mM. This approaches the aluminum concentrations found in brains of patients with several disorders which result in progressive dementia.

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Year:  1980        PMID： 7404592     DOI： 10.1016/0378-4274(80)90182-4

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  4 in total

1.  In ovo toxico-teratological effects of aluminum on embryonic chick heart and vascularization.

Authors:  Reda H ElMazoudy; Gamal A Bekhet
Journal:  Environ Sci Pollut Res Int       Date:  2016-08-18       Impact factor: 4.223

2.  Impairment of motor coordination in mice after ingestion of aluminum chloride.

Authors:  G Sahin; T Taşkin; K Benli; S Duru
Journal:  Biol Trace Elem Res       Date:  1995-10       Impact factor: 3.738

3.  Cell detachment and growth of fibroblasts as parameters for cytotoxicity of inorganic metal salts in vitro.

Authors:  C A Reinhardt; D A Pelli; M Sandvold
Journal:  Cell Biol Toxicol       Date:  1985-01       Impact factor: 6.691

Review 4.  Metabolism and possible health effects of aluminum.

Authors:  P O Ganrot
Journal:  Environ Health Perspect       Date:  1986-03       Impact factor: 9.031
  4 in total

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