Literature DB >> 7403881

Cerebral arteriolar damage by arachidonic acid and prostaglandin G2.

H A Kontos, E P Wei, J T Povlishock, W D Dietrich, C J Magiera, E F Ellis.   

Abstract

Application of arachidonic acid or prostaglandin G(2) to the brain surface of anesthetized cats induced cerebral arteriolar damage. Scavengers of free oxygen radicals inhibited this damage. Prostaglandin H(2), prostaglandin E(2), and 11,14,17-eicosatrienoic acid did not produce arteriolar damage. It appears that increased prostaglandin synthesis produces cerebral vascular damage by generating free oxygen radicals.

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Year:  1980        PMID： 7403881     DOI： 10.1126/science.7403881

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

1.  Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.

Authors:  C Iadecola; K Niwa; S Nogawa; X Zhao; M Nagayama; E Araki; S Morham; M E Ross
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-30       Impact factor: 11.205

2.  The contribution of arachidonic acid to the aetiology and pathophysiology of focal brain oedema; studies using an infusion oedema model.

Authors:  I R Whittle; I R Piper; J D Miller
Journal:  Acta Neurochir (Wien)       Date:  1991       Impact factor: 2.216

3.  Permeability and vasomotor response of cerebral vessels during exposure to arachidonic acid.

Authors:  A Unterberg; M Wahl; F Hammersen; A Baethmann
Journal:  Acta Neuropathol       Date:  1987       Impact factor: 17.088

4.  Photochemically induced cerebral infarction. I. Early microvascular alterations.

Authors:  W D Dietrich; B D Watson; R Busto; M D Ginsberg; J R Bethea
Journal:  Acta Neuropathol       Date:  1987       Impact factor: 17.088

Review 5.  Antiinflammatory and neuroprotective actions of COX2 inhibitors in the injured brain.

Authors:  Kenneth I Strauss
Journal:  Brain Behav Immun       Date:  2007-11-08       Impact factor: 7.217

6.  Oxidative mechanisms involved in kainate-induced cytotoxicity in cortical neurons.

Authors:  Y Cheng; A Y Sun
Journal:  Neurochem Res       Date:  1994-12       Impact factor: 3.996

7.  Experimental subarachnoid hemorrhage: events related to anti-oxidant enzymatic systems and eicosanoid peroxide enhancement.

Authors:  P Gaetani; R Rodriguez y Baena; S Quaglini; R Bellazzi; C Cafè; C Torri; F Marzatico
Journal:  Neurochem Res       Date:  1994-07       Impact factor: 3.996

8.  Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia.

Authors:  S Nogawa; C Forster; F Zhang; M Nagayama; M E Ross; C Iadecola
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

9.  Effect of GSH on cerebral vasospasm in dogs.

Authors:  S Haciyakupoğlu; F Ildan; S Polat; E Cetinalp; B Boyar; M Kaya
Journal:  Neurosurg Rev       Date:  1994       Impact factor: 3.042

10.  An ultrastructural analysis of endothelial change paralleling platelet aggregation in a light/dye model of microvascular insult.

Authors:  J T Povlishock; W I Rosenblum; M M Sholley; E P Wei
Journal:  Am J Pathol       Date:  1983-02       Impact factor: 4.307
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