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Literature DB >> 7403338

Phospholipase A activity and prostaglandin release from alveolar macrophages exposed to asbestos.

Abstract

The effect of asbestos (canadian chrysotile B) was studied on macrophages harvested by guinea-pig bronchoalveolar lavage. In short term incubation (3 hrs), asbestos (1 mg) induced a highly significant increase in macrophage phospholipase A activity and prostaglandin synthesis. At lower concentrations of the fibers (10 micrograms and 100 micrograms), no significant change of macrophage activity was noted following our incubation period. The modification by asbestos of membrane integrity and functions is suggested.

Entities: Chemical Species

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Year: 1980 PMID： 7403338 DOI： 10.1016/0161-4630(80)90088-9

Source DB: PubMed Journal: Prostaglandins Med ISSN： 0161-4630

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Cited

12 in total

1. Oxidant production by control and inflammatory bronchoalveolar leukocyte populations treated with mineral dusts in vitro.

Authors: K Donaldson; J Slight; R E Bolton
Journal: Inflammation Date: 1988-06 Impact factor: 4.092

2. Chemiluminescence of asbestos-activated macrophages.

Authors: K Donaldson; R T Cullen
Journal: Br J Exp Pathol Date: 1984-02

3. The selective release of phospholipase A2 by resident mouse peritoneal macrophages.

Authors: P D Wightman; M E Dahlgren; P Davies; R J Bonney
Journal: Biochem J Date: 1981-11-15 Impact factor: 3.857

4. Cellular and humoral components of bronchoalveolar lavage in the sheep.

Authors: M Rola-Pleszczynski; P Sirois; R Bégin
Journal: Lung Date: 1981 Impact factor: 2.584

5. Increased release of hydrogen peroxide and superoxide anion from asbestos-primed macrophages. Effect of hydrogen peroxide on the functional activity of alpha 1-protease inhibitor.

Authors: K Donaldson; J Slight; D Hannant; R E Bolton
Journal: Inflammation Date: 1985-06 Impact factor: 4.092

Phospholipase A activity and prostaglandin release from alveolar macrophages exposed to asbestos.

1. Oxidant production by control and inflammatory bronchoalveolar leukocyte populations treated with mineral dusts in vitro.

2. Chemiluminescence of asbestos-activated macrophages.

3. The selective release of phospholipase A2 by resident mouse peritoneal macrophages.

4. Cellular and humoral components of bronchoalveolar lavage in the sheep.

5. Increased release of hydrogen peroxide and superoxide anion from asbestos-primed macrophages. Effect of hydrogen peroxide on the functional activity of alpha 1-protease inhibitor.

6. Antibody producing cells in the spleens of mice treated with pathogenic mineral dust.

7. Arachidonic acid release and prostaglandin synthesis in a macrophage-like cell line exposed to asbestos.

8. Involvement of immunoglobulin E in the secretory processes of alveolar macrophages from asthmatic patients.

9. Interactions of asbestos-activated macrophages with an experimental fibrosarcoma.

Review 10. Biological in vitro and in vivo responses of chrysotile versus amphiboles.