| Literature DB >> 7402308 |
M Schachter, P Bédard, A G Debono, P Jenner, C D Marsden, P Price, J D Parkes, J Keenan, B Smith, J Rosenthaler, R Horowski, R Dorow.
Abstract
Dopamine receptors in intracerebral motor and endocrine systems have been divided into two main types, D-1 and D-2, dependent on the presence or absence of adenylate cyclase linkage. Here we have investigated a number of dopamine agonist and antagonist drugs in man that have different actions on D-1 and D-2 receptors in animals. Motor and endocrine effects in parkinsonian subjects seem to depend on drug interaction with D-2, but not D-1, receptors. These results may have important implications for the design of anti-parkinsonian and antipsychotic agents.Entities:
Mesh：
Substances：
Year: 1980 PMID： 7402308 DOI： 10.1038/286157a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962