| Literature DB >> 7402087 |
R Heuman, U Larsson-Cohn, M Hammar, H G Tiselius.
Abstract
Bile composition was studied in three postmenopausal women without evidence of gallstone disease during administration of 50 micrograms of ethinylestradiol daily. The treatment resulted in an increased fraction of cholesterol in gallbladder bile and a shift in the bile acid composition with decreased relative concentration of chenodeoxycholate and increased fraction of cholate. These changes in bile lipid composition might explain the higher incidence of gallstones in women treated with estrogens.Entities:
Keywords: Acceptor Characteristics; Age Factors; Clinical Research; Contraception; Contraceptive Agents, Estrogen--administraction and dosage; Contraceptive Agents, Estrogen--side effects; Contraceptive Agents, Female--administraction and dosage; Contraceptive Agents, Female--side effects; Contraceptive Agents--administraction and dosage; Contraceptive Agents--side effects; Contraceptive Methods--side effects; Demographic Factors; Diseases; Ethinyl Estradiol--administraction and dosage; Ethinyl Estradiol--side effects; Family Planning; Gallbladder Diseases; Human Volunteers; Menopause; Oral Contraceptives--side effects; Population; Population Characteristics; Reproduction; Research Methodology
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Year: 1980 PMID： 7402087 DOI： 10.1016/0378-5122(80)90062-6
Source DB: PubMed Journal: Maturitas ISSN： 0378-5122 Impact factor: 4.342