Literature DB >> 7400935

High-pressure liquid chromatographic assay for chloramphenicol, chloramphenicol-3-monosuccinate, and chloramphenicol-1-monosuccinate.

J T Burke, W A Wargin, M R Blum.   

Abstract

A high-pressure liquid chromatographic method for the sensitive and rapid determination of chloramphenicol, chloramphenicol-3-monosuccinate, and chloramphenicol-1-monosuccinate is presented. The procedure utilizes a reversed-phase chromatographic column with UV absorption detection. The assay is useful for monitoring patients receiving chloramphenicol, determining the pharmacokinetics of parenteral chloramphenicol sodium succinate, and certifying sterile chloramphenicol sodium succinate.

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Year:  1980        PMID： 7400935     DOI： 10.1002/jps.2600690813

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  3 in total

Review 1.  Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate.

Authors:  P J Ambrose
Journal:  Clin Pharmacokinet       Date:  1984 May-Jun       Impact factor: 6.447

2.  Analysis of the mechanism of chloramphenicol acetyltransferase by steady-state kinetics. Evidence for a ternary-complex mechanism.

Authors:  C Kleanthous; W V Shaw
Journal:  Biochem J       Date:  1984-10-01       Impact factor: 3.857

3.  Pharmacokinetics of intravenous chloramphenicol sodium succinate in adult patients with normal renal and hepatic function.

Authors:  J T Burke; W A Wargin; R J Sherertz; K L Sanders; M R Blum; F A Sarubbi
Journal:  J Pharmacokinet Biopharm       Date:  1982-12
  3 in total

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