| Literature DB >> 7400832 |
T S Wang, R A Fawwaz, L J Johnson, G E Mojdehi, P M Johnson.
Abstract
Carbonyl diphosphonic acid, dihydroxy-methylene diphosphonic acid and monohydroxy-methylene diphosphonic acid were synthesized and labeled with Tc-99m. Their chemical structures were confirmed and their bone-seeking relationships were compared with those of Tc-99m MDP in experimental animals. MKonohydroxy-methylene diphosphonic acid was found to have higher bone affinity and faster blood clearance than MDP, whereas carabonyl diphosphonic acid and dihydroxy-methylene diphosphonic acid demonstrated lower bone affinity and slower blood clearance than MDP.Entities:
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Year: 1980 PMID： 7400832
Source DB: PubMed Journal: J Nucl Med ISSN： 0161-5505 Impact factor: 10.057