Literature DB >> 7400754

Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments.

E L Morgan, S M Walker, M L Thoman, W O Weigle.   

Abstract

Fc fragments derived from human and murine Ig were found to be potent adjuvants when administered with antigen. Both the in vivo and in vitro anti- sheep erythrocytes (SRBC) responses were significantly enhanced by Fc fragments. The adjuvant effect was shown to be extremely dependent upon the dose of antigen used, with the greatest enhancement occurring when suboptimal doses of antigen are employed. The anti-genicity of the Fc molecule was not related to its adjuvanticity because homologous Fc was as potent an adjuvant as heterologous Fc. Moreover, human Fc fragments enhanced anti-SRBC responses in mice which were tolerant to human gamma globulin.

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Year:  1980        PMID： 7400754      PMCID： PMC2185893          DOI： 10.1084/jem.152.1.113

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  30 in total

1.  Studies on the control of antibody synthesis. Effect of antibody affinity upon its ability to suppress antibody formation.

Authors:  J G Walker; G W Siskind
Journal:  Immunology       Date:  1968-01       Impact factor: 7.397

2.  A modification of the hemolytic plaque assay for use with protein antigens.

Authors:  E S Golub; R I Mishell; W O Weigle; R W Dutton
Journal:  J Immunol       Date:  1968-01       Impact factor: 5.422

3.  The immune response suppressed by specific antibody.

Authors:  D A Rowley; F W Fitch; M A Axelrad; C W Pierce
Journal:  Immunology       Date:  1969-04       Impact factor: 7.397

4.  Immunosuppression by antibody: localization of site of action.

Authors:  R J Ryder; R S Schwartz
Journal:  J Immunol       Date:  1969-11       Impact factor: 5.422

5.  The response of lymphocytes from non-immunized humans to antigen-antibody complexes.

Authors:  N Bloch-Shtacher; K Hirschhorn; J W Uhr
Journal:  Clin Exp Immunol       Date:  1968-11       Impact factor: 4.330

6.  The immunosuppressive effect of passively administered antibody IgG fragments.

Authors:  J C Cerottini; P J McConahey; F J Dixon
Journal:  J Immunol       Date:  1969-04       Impact factor: 5.422

7.  Specificity of the immunosuppression caused by passive administration of antibody.

Authors:  J C Cerottini; P J McConahey; F J Dixon
Journal:  J Immunol       Date:  1969-08       Impact factor: 5.422

8.  Enhanced immunologic sensitization of mice by the simultaneous injection of antigen and specific antiserum. II. Effect of varying the antigen-antibody ratio and the amount of immune complex injected.

Authors:  S L Morrison; G Terres
Journal:  J Immunol       Date:  1966-05       Impact factor: 5.422

9.  Regulation of the immune response. I. Reduction in ability of specific antibody to inhibit long-lasting IgG immunological priming after removal of the Fc fragment.

Authors:  R Nicholas; S C Sinclair
Journal:  J Exp Med       Date:  1969-06-01       Impact factor: 14.307

10.  Immunization of dissociated spleen cell cultures from normal mice.

Authors:  R I Mishell; R W Dutton
Journal:  J Exp Med       Date:  1967-09-01       Impact factor: 14.307
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  14 in total

1.  Isolation and identification of a biologically active peptide derived from the CH3 domain of human IgG1.

Authors:  E L Morgan; T E Hugli; W O Weigle
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

Review 2.  The role of complement in the induction and regulation of immune responses.

Authors:  T G Egwang; A D Befus
Journal:  Immunology       Date:  1984-02       Impact factor: 7.397

Review 3.  Regulation of immune response by components of the complement cascade and their activated fragments.

Authors:  W O Weigle; M G Goodman; E L Morgan; T E Hugli
Journal:  Springer Semin Immunopathol       Date:  1983

4.  Potentiation of specific human in vitro immune responses by the Fc portion of human immunoglobulin.

Authors:  E L Morgan; W O Weigle
Journal:  Clin Exp Immunol       Date:  1983-08       Impact factor: 4.330

5.  Studies of the immunological activities of the outer membrane protein from Escherichia coli.

Authors:  S Mohri; T Watanabe; H Nariuchi
Journal:  Immunology       Date:  1982-06       Impact factor: 7.397

Review 6.  Fc receptor--more answers, more questions.

Authors:  L Fornůsek; V Vĕtvicka
Journal:  Folia Microbiol (Praha)       Date:  1984       Impact factor: 2.099

7.  Reversal of immune complex inhibition of antibody-dependent cell-mediated cytotoxicity by normal human serum.

Authors:  M A Isturiz; S B Fink; M M de Bracco
Journal:  Clin Exp Immunol       Date:  1982-06       Impact factor: 4.330

8.  Role of complement and the Fc portion of immunoglobulin G in immunity to Venezuelan equine encephalomyelitis virus infection with glycoprotein-specific monoclonal antibodies.

Authors:  J H Mathews; J T Roehrig; D W Trent
Journal:  J Virol       Date:  1985-09       Impact factor: 5.103

9.  Prevention and treatment of influenza with hyperimmune bovine colostrum antibody.

Authors:  Wy Ching Ng; Victor Wong; Brian Muller; Grant Rawlin; Lorena E Brown
Journal:  PLoS One       Date:  2010-10-26       Impact factor: 3.240

10.  Enhancement of T lymphocyte functions by Fc fragments of immunoglobulins. I. Augmentation of allogeneic mixed lymphocyte culture reactions requires I-A- or I-B-subregion differences between effector and stimulator cell populations.

Authors:  E L Morgan; M L Thoman; W O Weigle
Journal:  J Exp Med       Date:  1981-05-01       Impact factor: 14.307
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