Literature DB >> 740048

The effect of acute and chronic desipramine and amitriptyline treatment on rat brain total 3methoxy-4-hydroxyphenylglycol.

S W Tang, D M Helmeste, H C Stancer.   

Abstract

The effect of acute (single dose), short-term (4 days), and chronic treatment (21 days) with two tricyclic antidepressants desipramine and amitriptyline on brain 3-methoxy-4-hydroxyphenylglycol (MHPG) was examined in the rat. Amitriptyline had no effect on brain total MHPG irrespective of the duration of the treatment and did not interfere with the lowering effect of clonidine on brain total MHPG. Acute and short-term desipramine treatment decreased brain total MHPG in rats, while chronic desipramine treatment increased it. The differential effect of acute and chronic treatment of desipramine on the brain total MHPG was further demonstrated by the lack of interference with the lowering effect of clonidine on brain total MHPG by one single dose of desipramine; partial interference after 4 days and complete interference after 21 days of desipramine treatment.

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Year:  1978        PMID： 740048     DOI： 10.1007/bf00498812

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  24 in total

1.  Effect of drugs on the uptake and metabolism of H3-norepinephrine.

Authors:  G HERTING; J AXELROD; L G WHITBY
Journal:  J Pharmacol Exp Ther       Date:  1961-11       Impact factor: 4.030

2.  INHIBITION OF UPTAKE OF TRITIATED-NORADRENALINE IN THE INTACT RAT BRAIN BY IMIPRAMINE AND STRUCTURALLY RELATED COMPOUNDS.

Authors:  J GLOWINSKI; J AXELROD
Journal:  Nature       Date:  1964-12-26       Impact factor: 49.962

3.  Mass fragmentographic determination of some acidic and alcoholic metabolites of biogenic amines in the rat brain.

Authors:  F Karoum; J C Gillin; R J Wyatt
Journal:  J Neurochem       Date:  1975-11       Impact factor: 5.372

4.  Development of beta-adrenergic receptor subsensitivity by antidepressants.

Authors:  S P Banerjee; L S Kung; S J Riggi; S K Chanda
Journal:  Nature       Date:  1977-08-04       Impact factor: 49.962

5.  Effects of short-and long-term administration of tricyclic antidepressants and lithium on norepinephrine turnover in brain.

Authors:  J J Schildkraut; M Roffman; P J Orsulak; A F Schatzberg; M A Kling; T G Reigle
Journal:  Pharmakopsychiatr Neuropsychopharmakol       Date:  1976-07

6.  Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents.

Authors:  N E Andén; M Grabowska; U Strömbom
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

7.  Effect of antidepressant drugs on accumulation and disappearance of monoamines formed in vivo from labelled precursors in mouse brain.

Authors:  J Schubert; H Nybäck; G Sedvall
Journal:  J Pharm Pharmacol       Date:  1970-02       Impact factor: 3.765

8.  Accumulation and disappearance of noradrenaline and its major metabolites synthesized from intraventricularly injected (3H)dopamine in the rat brain.

Authors:  C Braestrup; M Nielsen; J Scheel-Krüger
Journal:  J Neurochem       Date:  1974-09       Impact factor: 5.372

9.  The interference of tricyclic antidepressants with the central hypotensive effect of clonidine.

Authors:  H W van Spanning; P A van Zwieten
Journal:  Eur J Pharmacol       Date:  1973-12       Impact factor: 4.432

Review 10.  The catecholamine hypothesis of affective disorders: a review of supporting evidence.

Authors:  J J Schildkraut
Journal:  Am J Psychiatry       Date:  1965-11       Impact factor: 18.112
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  11 in total

1.  The effects of acute and repeated treatment with salbutamol, a beta-adrenoceptor agonist, on clonidine-induced hypoactivity in rats.

Authors:  E Mogilnicka
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575

2.  Effects of combined administration of L-tryptophan and tricyclic antidepressants on alpha 2- and beta-adrenoceptors and monoamine levels in rat brain.

Authors:  V A Russell; M C Lamm; A S de Villiers; J J Taljaard; D O Chalton
Journal:  Neurochem Res       Date:  1985-12       Impact factor: 3.996

3.  An investigation of the role of 5-hydroxytryptamine in the attenuation of presynaptic alpha 2-adrenoceptor-mediated responses by antidepressant treatments.

Authors:  D J Heal; E M Hurst; M R Prow; W R Buckett
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

4.  Tricyclic antidepressants vary in decreasing alpha 2-adrenoceptor sensitivity with chronic treatment: assessment with clonidine inhibition of acoustic startle.

Authors:  M Davis; D B Menkes
Journal:  Br J Pharmacol       Date:  1982-10       Impact factor: 8.739

5.  Effect of chronic clonidine treatment on the turnover of noradrenaline and dopamine in various regions of the rat brain.

Authors:  L Rochette; A M Bralet; J Bralet
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-04       Impact factor: 3.000

6.  Influence of salbutamol and other beta-agonists on hypothermia induced by clonidine, apomorphine and reserpine in mice.

Authors:  M Müller; E Mogilnicka
Journal:  J Neural Transm       Date:  1981       Impact factor: 3.575

7.  Chronic treatment with some atypical antidepressants increases the brain level of 3-methoxy-4-hydroxyphenylglycol (MHPG) in rats.

Authors:  E Przegaliński; A Kordecka-Magiera; E Mogilnicka; J Maj
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

8.  Effects of antidepressant drugs and electroconvulsive shock on pre- and postsynaptic alpha 2-adrenoceptor function in the brain: rapid down-regulation by sibutramine hydrochloride.

Authors:  D J Heal; M R Prow; W R Buckett
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

9.  Evaluation of the levels of free and total amitriptyline and metabolites in the plasma and brain of the rat after long-term administration of doses used in receptor studies.

Authors:  P Baumann; J M Gaillard; M Jonzier-Perey; C Gerber; C Bouras
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

10.  Presynaptic alpha-adrenoceptors and the action of tricyclic antidepressant drugs in behavioural despair in rats.

Authors:  I Zebrowska-Lupina
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530
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