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Literature DB >> 7399686

Production of Clostridium difficile antitoxin.

M Ehrich, R L Van Tassell, J M Libby, T D Wilkins.

Abstract

We have produced antitoxin to the toxin of Clostridium difficile in rabbits and in goats. Antitoxin dilutions of 1/8,000 and 1/5,120 were capable of neutralizing lethal doses of the toxin in mice and in tissue culture, respectively.

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Year: 1980 PMID： 7399686 PMCID： PMC551056 DOI： 10.1128/iai.28.3.1041-1043.1980

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

9 in total

1. Comparison of five regimens for treatment of experimental clindamycin-associated colitis.

Authors: J G Bartlett; T W Chang; A B Onderdonk
Journal: J Infect Dis Date: 1978-07 Impact factor: 5.226

2. Identification of Clostridium difficile as a cause of pseudomembranous colitis.

Authors: R H George; J M Symonds; F Dimock; J D Brown; Y Arabi; N Shinagawa; M R Keighley; J Alexander-Williams; D W Burdon
Journal: Br Med J Date: 1978-03-18

3. Colitis induced by Clostridium difficile.

Authors: J G Bartlett; T Chang; N S Taylor; A B Onderdonk
Journal: Rev Infect Dis Date: 1979 Mar-Apr

4. Neutralization of Clostridium difficile toxin by Clostridium sordellii antitoxins.

Authors: T W Chang; S L Gorbach; J B Bartlett
Journal: Infect Immun Date: 1978-11 Impact factor: 3.441

5. Prevention of clindamycin-induced colitis in hamsters by Clostridium sordellii antitoxin.

Authors: M Allo; J Silva; R Fekety; G D Rifkin; H Waskin
Journal: Gastroenterology Date: 1979-02 Impact factor: 22.682

6. Clindamycin-induced enterocolitis in hamsters as a model of pseudomembranous colitis in patients.

Authors: T W Chang; J G Bartlett; S L Gorbach; A B Onderdonk
Journal: Infect Immun Date: 1978-05 Impact factor: 3.441

7. Aetiology of antimicrobial-agent-associated colitis.

Authors: W L George; V L Sutter; E J Goldstein; S L Ludwig; S M Finegold
Journal: Lancet Date: 1978-04-15 Impact factor: 79.321

8. Pseudomembranous colitis: Presence of clostridial toxin.

Authors: H E Larson; A B Price
Journal: Lancet Date: 1977 Dec 24-31 Impact factor: 79.321

9. Antibiotic-induced colitis implication of a toxin neutralised by Clostridium sordellii antitoxin.

Authors: G D Rifkin; F R Fekety; J Silva
Journal: Lancet Date: 1977-11-26 Impact factor: 79.321

9 in total

44 in total

1. Toxin A of Clostridium difficile is a potent cytotoxin.

Authors: K D Tucker; P E Carrig; T D Wilkins
Journal: J Clin Microbiol Date: 1990-05 Impact factor: 5.948

2. Passive immunization of hamsters against disease caused by Clostridium difficile by use of bovine immunoglobulin G concentrate.

Authors: D M Lyerly; E F Bostwick; S B Binion; T D Wilkins
Journal: Infect Immun Date: 1991-06 Impact factor: 3.441

3. Antigenic cross-reactivity and functional inhibition by antibodies to Clostridium difficile toxin A, Streptococcus mutans glucan-binding protein, and a synthetic peptide.

Authors: B W Wren; R R Russell; S Tabaqchali
Journal: Infect Immun Date: 1991-09 Impact factor: 3.441

4. Molecular characterization of the Clostridium difficile toxin A gene.

Authors: C H Dove; S Z Wang; S B Price; C J Phelps; D M Lyerly; T D Wilkins; J L Johnson
Journal: Infect Immun Date: 1990-02 Impact factor: 3.441

5. Evaluation of formalin-inactivated Clostridium difficile vaccines administered by parenteral and mucosal routes of immunization in hamsters.

Authors: J F Torres; D M Lyerly; J E Hill; T P Monath
Journal: Infect Immun Date: 1995-12 Impact factor: 3.441

6. Presence of Clostridium difficile toxin in guinea pigs with penicillin-associated colitis.

Authors: S W Rothman
Journal: Med Microbiol Immunol Date: 1981 Impact factor: 3.402

7. Purified Clostridium difficile cytotoxin stimulates guanylate cyclase activity and inhibits adenylate cyclase activity.

Authors: D L Vesely; K D Straub; C M Nolan; R D Rolfe; S M Finegold; T P Monson
Journal: Infect Immun Date: 1981-07 Impact factor: 3.441