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Literature DB >> 7399542

Detection of teratogenic compounds using differentiating embryonic cells in culture.

A L Wilk, J H Greenberg, E A Horigan, R M Pratt, G R Martin.

Abstract

Methods are described for screening for teratogenic compounds using differentiating neural crest and prechondrogenic limb bud mesenchyme cells in culture. Substances to be tested are either added directly to the culture medium or are combined in a dialysis bag with the postmitochondrial fraction from rat liver and certain cofactors. In the latter case, the compound and its metabolites are gradually released into the medium from the dialysis bag. The results obtained with 14 compounds demonstrate a positive relationship between teratogenicity in vivo and alterations in the growth or the differentiation of the cultured cells.

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Year: 1980 PMID： 7399542 DOI： 10.1007/bf02618331

Source DB: PubMed Journal: In Vitro ISSN： 0073-5655

21 in total

Review 1. Short term screening tests for carcinogens.

Authors: B A Bridges
Journal: Nature Date: 1976-05-20 Impact factor: 49.962

2. A series of normal stages in the development of the chick embryo.

Authors: V HAMBURGER; H L HAMILTON
Journal: J Morphol Date: 1951-01 Impact factor: 1.804

3. Abortive effects and comparative metabolism of chlorcyclizine in various mammalian species.

Authors: A J Steffek; C T King; A L Wilk
Journal: Teratology Date: 1968-11

4. Production of fetal rat malformations by norchlorcyclizine and chlorcyclizine after intrauterine application.

Authors: A L Wilk
Journal: Teratology Date: 1969-02

Review 5. Cross-linking of collagen and elastin.

Authors: K A Piez
Journal: Annu Rev Biochem Date: 1968 Impact factor: 23.643

6. Metabolism of -aminopropionitrile and its teratogenic activity in rats.

Authors: A L Wilk; C T King; E A Horigan; A J Steffek
Journal: Teratology Date: 1972-02

7. Teratogenic effects of diphenylhydantoin in Swiss-Webster and A-J mice.

Authors: J E Gibson; B A Becker
Journal: Proc Soc Exp Biol Med Date: 1968-07

8. The effect of cell population density on the developmental fate of reaggregating mouse limb bud mesenchyme.

Authors: R Umansky
Journal: Dev Biol Date: 1966-02 Impact factor: 3.582

9. Studies on metabolism and identification of the causative agent in aspirin teratogenesis in rats.

Authors: C A Kimmel; J G Wilson; H J Schumacher
Journal: Teratology Date: 1971-02

10. Induction of craniofacial malformations in rhesus monkeys (Macaca mulatta) with cyclophosphamide.

Authors: H M Mcclure; A L Wilk; E A Horigan; R M Pratt
Journal: Cleft Palate J Date: 1979-07

12 in total

1. Extensive growth and differentiation of limb bud cells grown on polycarbonate membranes.

Authors: A Kistler; B Wessner
Journal: In Vitro Cell Dev Biol Date: 1991-01

2. Differential effects of prenatal exposure to phenobarbital on the behaviour and neurochemistry of CBA and C57BL/6J mice.

Authors: S K Sedowofia; J Innes; A Peter; E Alleva; A Manning; R M Clayton
Journal: Psychopharmacology (Berl) Date: 1989 Impact factor: 4.530

3. Limb bud cell cultures for estimating the teratogenic potential of compounds. Validation of the test system with retinoids.

Authors: A Kistler
Journal: Arch Toxicol Date: 1987-08 Impact factor: 5.153

Detection of teratogenic compounds using differentiating embryonic cells in culture.

Review 1. Short term screening tests for carcinogens.

2. A series of normal stages in the development of the chick embryo.

3. Abortive effects and comparative metabolism of chlorcyclizine in various mammalian species.

4. Production of fetal rat malformations by norchlorcyclizine and chlorcyclizine after intrauterine application.

Review 5. Cross-linking of collagen and elastin.

6. Metabolism of -aminopropionitrile and its teratogenic activity in rats.

7. Teratogenic effects of diphenylhydantoin in Swiss-Webster and A-J mice.

8. The effect of cell population density on the developmental fate of reaggregating mouse limb bud mesenchyme.

9. Studies on metabolism and identification of the causative agent in aspirin teratogenesis in rats.

10. Induction of craniofacial malformations in rhesus monkeys (Macaca mulatta) with cyclophosphamide.

1. Extensive growth and differentiation of limb bud cells grown on polycarbonate membranes.

2. Differential effects of prenatal exposure to phenobarbital on the behaviour and neurochemistry of CBA and C57BL/6J mice.

3. Limb bud cell cultures for estimating the teratogenic potential of compounds. Validation of the test system with retinoids.

4. Embryolethality of new herbicides is not detected by the micromass teratogen tests.

5. Microtiter micromass cultures of limb-bud mesenchymal cells.

6. Teratogenicity of arotinoids (retinoids) in vivo and in vitro.

7. Characterization of cytoskeletal and neuronal markers in micromass cultures of rat embryonic midbrain cells.

8. Transplacental movement of inorganic lead in early and late gestation in the mouse.

9. Effects of anticonvulsants on cholinergic and GABAergic properties in the neuronal cell clone NG108-15.

10. Comparative teratogenicity of nine retinoids in the rat.