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Literature DB >> 7399320

A search for persistent virus infection in Crohn's disease.

R J Phillpotts, J Hermon-Taylor, N M Teich, B N Brooke.

Abstract

Cell cultures derived from Crohn's disease and control tissues were subjected to a series of tests designed to detect persistent, non-cytocidal virus infection. No evidence for any such infection was found, and it is concluded that persistent viral infection of gut tissues is unlikely to play a significant role in the pathogenesis of Crohn's disease.

Entities: Disease

Mesh：

Year: 1980 PMID： 7399320 PMCID： PMC1420358 DOI： 10.1136/gut.21.3.202

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

18 in total

1. Trypsinization of monkey-kidney tissue: an automatic method for the preparation of cell suspensions.

Authors: C RAPPAPORT
Journal: Bull World Health Organ Date: 1956 Impact factor: 9.408

2. Interferon production in L cells persistently infected with hemagglutinating virus of Japan (HVJ).

Authors: Y Ito; Y Nishiyama; K Shimokata; Y Kimura; I Nagata; A Kunii
Journal: Virology Date: 1976-06 Impact factor: 3.616

3. Mink cell line Mv 1 Lu (CCL 64). Focus formation and the generation of "nonproducer" transformed cell lines with murine and feline sarcoma viruses.

Authors: I C Henderson; M M Lieber; G J Todaro
Journal: Virology Date: 1974-07 Impact factor: 3.616

4. Persistent infection of mouse cells with Sindbis virus: role of virulence of strains, auto-interfering particles and interferon.

Authors: A D Inglot; M Albin; T Chudzio
Journal: J Gen Virol Date: 1973-07 Impact factor: 3.891

5. Noninfectious AKR mouse embryo cell lines in which each cell has the capacity to be activated to produce infectious murine leukemia virus.

Authors: W P Rowe; J W Hartley; M R Lander; W E Pugh; N Teich
Journal: Virology Date: 1971-12 Impact factor: 3.616

6. Characteristics of a human diploid cell designated MRC-5.

Authors: J P Jacobs; C M Jones; J P Baille
Journal: Nature Date: 1970-07-11 Impact factor: 49.962

Review 7. The reverse transcriptase.

Authors: I M Verma
Journal: Biochim Biophys Acta Date: 1977-03-21

2. The electrophoretic analysis of low molecular weight nucleic acids from Crohn's disease tissues in the search for an unconventional small infectious agent. Brief report.

Authors: P D Butcher; J J McFadden; J Hermon-Taylor
Journal: Arch Virol Date: 1986 Impact factor: 2.574

Review 3. The aetiology of Crohn's disease.

Authors: G N Tytgat; C J Mulder
Journal: Int J Colorectal Dis Date: 1986-07 Impact factor: 2.571

Review 7. Review of general surgery 1980.

Authors: H Ellis
Journal: Postgrad Med J Date: 1981-06 Impact factor: 2.401

A search for persistent virus infection in Crohn's disease.

1. Trypsinization of monkey-kidney tissue: an automatic method for the preparation of cell suspensions.

2. Interferon production in L cells persistently infected with hemagglutinating virus of Japan (HVJ).

3. Mink cell line Mv 1 Lu (CCL 64). Focus formation and the generation of "nonproducer" transformed cell lines with murine and feline sarcoma viruses.

4. Persistent infection of mouse cells with Sindbis virus: role of virulence of strains, auto-interfering particles and interferon.

5. Noninfectious AKR mouse embryo cell lines in which each cell has the capacity to be activated to produce infectious murine leukemia virus.

6. Characteristics of a human diploid cell designated MRC-5.

Review 7. The reverse transcriptase.

8. Experimental animal studies of the etiology and pathogenesis of Crohn's disease.

9. Primer requirement and template specificity of the DNA polymerase of RNA tumor viruses.

10. Induction of granulomas in mice by Crohn's disease tissue.

1. Immunoprecipitation of antigen-associated [32P]-labelled nucleic acids from Crohn's disease mesenteric lymph nodes.

2. The electrophoretic analysis of low molecular weight nucleic acids from Crohn's disease tissues in the search for an unconventional small infectious agent. Brief report.

Review 3. The aetiology of Crohn's disease.

Review 4. Idiopathic Inflammation Bowel Disease: is there a role for immunological mechanisms in etiopathogenesis?

Review 5. Assessment of drug therapy in inflammatory bowel disease.

6. Immunity to cytopathic agents associated with Crohn's disease: a negative study.

Review 7. Review of general surgery 1980.

8. Search for evidence of a viral aetiology for inflammatory bowel disease.

Review 9. Animal models of inflammatory bowel disease--an overview.

10. Lack of association of cytomegalovirus with adenocarcinoma of the colon.