Literature DB >> 7399318

Hydrolysis of pyridoxal-5'-phosphate in plasma in conditions with raised alkaline phosphate.

B B Anderson, H O'Brien, G E Griffin, D L Mollin.   

Abstract

Hydrolysis of pyridoxal phosphate in plasma was demonstrated in patients with liver disease and other conditions with raised alkaline phosphatase, and this usually closely paralleled the alkaline phosphatase level, whether of liver or bone origin. The endogenous plasma pyridoxal phosphate was inversely related to the alkaline phosphatase, and plasma hydrolysis of pyridoxal phosphate may at least in part be responsible. Very large doses of vitamin B6 may be necessary to compensate for this hydrolysis.

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Year:  1980        PMID： 7399318      PMCID： PMC1420355          DOI： 10.1136/gut.21.3.192

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  9 in total

1.  The specific binding of pyridoxal 5'-phosphate to bovine plasma albumin.

Authors:  W B DEMPSEY; H N CHRISTENSEN
Journal:  J Biol Chem       Date:  1962-04       Impact factor: 5.157

2.  Pyridoxal phosphate breakdown by an alkaline-phosphatase preparation.

Authors:  J M TURNER
Journal:  Biochem J       Date:  1961-09       Impact factor: 3.857

3.  Plasma binding of vitamin B6 compounds.

Authors:  B B Anderson; P A Newmark; M Rawlins; R Green
Journal:  Nature       Date:  1974-08-09       Impact factor: 49.962

4.  Pyridoxal 5'-phosphate in plasma: source, protein-binding, and cellular transport.

Authors:  L Lumeng; R E Brashear; T K Li
Journal:  J Lab Clin Med       Date:  1974-09

Review 5.  Vitamins and liver injury.

Authors:  C M Leevy; A Thompson; H Baker
Journal:  Am J Clin Nutr       Date:  1970-04       Impact factor: 7.045

6.  Vitamin B6 deficiency in chronic liver disease--evidence for increased degradation of pyridoxal-5'-phosphate.

Authors:  D Labadarios; J E Rossouw; J B McConnell; M Davis; R Williams
Journal:  Gut       Date:  1977-01       Impact factor: 23.059

7.  The measurement of serum pyridoxal by a microbiological assay using Lactobacillus casei.

Authors:  B B Anderson; M B Peart; C E Fulford-Jones
Journal:  J Clin Pathol       Date:  1970-04       Impact factor: 3.411

8.  Abnormal regulation of plasma pyridoxal 5'-phosphate in patients with liver disease.

Authors:  D Mitchell; C Wagner; W J Stone; G R Wilkinson; S Schenker
Journal:  Gastroenterology       Date:  1976-12       Impact factor: 22.682

9.  Conversion of vitamin B 6 compounds to active forms in the red blood cell.

Authors:  B B Anderson; C E Fulford-Jones; J A Child; M E Beard; C J Bateman
Journal:  J Clin Invest       Date:  1971-09       Impact factor: 14.808
  9 in total
  8 in total

Review 1.  Direct and Functional Biomarkers of Vitamin B6 Status.

Authors:  Per Magne Ueland; Arve Ulvik; Luisa Rios-Avila; Øivind Midttun; Jesse F Gregory
Journal:  Annu Rev Nutr       Date:  2015-05-13       Impact factor: 11.848

2.  Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5'-Phosphate Concentration in Healthy Adults.

Authors:  Tonia C Carter; Faith Pangilinan; Anne M Molloy; Ruzong Fan; Yifan Wang; Barry Shane; Eileen R Gibney; Øivind Midttun; Per M Ueland; Cheryl D Cropp; Yoonhee Kim; Alexander F Wilson; Joan E Bailey-Wilson; Lawrence C Brody; James L Mills
Journal:  J Nutr       Date:  2015-05-13       Impact factor: 4.798

3.  Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase.

Authors:  M P Whyte; J D Mahuren; K N Fedde; F S Cole; E R McCabe; S P Coburn
Journal:  J Clin Invest       Date:  1988-04       Impact factor: 14.808

4.  Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy.

Authors:  M P Whyte; M Landt; L M Ryan; R A Mulivor; P S Henthorn; K N Fedde; J D Mahuren; S P Coburn
Journal:  J Clin Invest       Date:  1995-04       Impact factor: 14.808

5.  Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism.

Authors:  M P Whyte; J D Mahuren; L A Vrabel; S P Coburn
Journal:  J Clin Invest       Date:  1985-08       Impact factor: 14.808

6.  Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.

Authors:  Aditi Hazra; Peter Kraft; Ross Lazarus; Constance Chen; Stephen J Chanock; Paul Jacques; Jacob Selhub; David J Hunter
Journal:  Hum Mol Genet       Date:  2009-09-10       Impact factor: 6.150

7.  Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.

Authors:  Toshiko Tanaka; Paul Scheet; Betti Giusti; Stefania Bandinelli; Maria Grazia Piras; Gianluca Usala; Sandra Lai; Antonella Mulas; Anna Maria Corsi; Anna Vestrini; Francesco Sofi; Anna Maria Gori; Rosanna Abbate; Jack Guralnik; Andrew Singleton; Goncalo R Abecasis; David Schlessinger; Manuela Uda; Luigi Ferrucci
Journal:  Am J Hum Genet       Date:  2009-03-19       Impact factor: 11.025

8.  Inflammation causes tissue-specific depletion of vitamin B6.

Authors:  En-Pei Chiang; Donald E Smith; Jacob Selhub; Gerard Dallal; Yi-Cheng Wang; Ronenn Roubenoff
Journal:  Arthritis Res Ther       Date:  2005-09-13       Impact factor: 5.156
  8 in total

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