| Literature DB >> 7398769 |
Abstract
Binding of [3H]5-HT was studied using purified neuronal membranes isolated from horse brain striatum. It is shown that the preincubation of these membranes with an agonist (5-HT, bufotenin) followed by washing, modified the binding of [3H]5-HT from a low affinity to a high affinity constant. This effect was blocked by previous pretreatment of the membranes with a sulfhydryl group reagent (N-ethylmaleimide) and was reversed by guanoside 5'-triphosphate.Entities:
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Year: 1980 PMID： 7398769 DOI： 10.1016/0014-2999(80)90218-6
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432