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Literature DB >> 7396848

Tryptophan pyrrolase in haem regulation. The mechanism of the permissive effect of cortisol on the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide in the adrenalectomized-rat liver.

Abstract

The decreased ability of 2-allyl-2-isopropropylacetamide to enhance liver 5-amino-laevulinate synthase activity in the adrenalectomized rat is not associated with a marked depletion of the already low amount of tryptophan pyrrolase haem. Cortisol permits the porphyrogen markedly to enhance synthase activity by rendering it capable of causing a stronger depletion of pyrrolase haem, presumably as result of hormonal induction of pyrrolase synthesis.

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Year: 1980 PMID： 7396848 PMCID： PMC1161739 DOI： 10.1042/bj1860993

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

14 in total

Review 1. The effect of drugs on 5-aminolaevulinate synthetase and other enzymes in the pathway of liver haem biosynthesis.

Authors: F De Matteis
Journal: Basic Life Sci Date: 1975

2. Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition.

Authors: S Granick; P Sinclair; S Sassa; G Grieninger
Journal: J Biol Chem Date: 1975-12-25 Impact factor: 5.157

3. Regulation of rat liver tryptophan pyrrolase by its cofactor haem: Experiments with haematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms.

Authors: A A Badawy; M Evans
Journal: Biochem J Date: 1975-09 Impact factor: 3.857

4. Glucose effect on tryptophan oxygenase and tyrosine aminotransferase induction after allylisopropylacetamide-induced porphyria in the rat.

Authors: L Wetterberg; E Geller; A Yuwiler
Journal: Biochem Pharmacol Date: 1970-11 Impact factor: 5.858

5. Effect of adrenalectomy and cortisone administration on components of the liver microsomal mixed function oxygenase system of male rats which catalyzes ethylmorphine metabolism.

Authors: J A Castro; F E Greene; P Gigon; H Sasame; J R Gillette
Journal: Biochem Pharmacol Date: 1970-08 Impact factor: 5.858

9. The mechanism of inhibition of rat liver tryptophan pyrrolase activity by 4-hydroxypyrazolo(3,4-d)pyrimidine (Allopurinol).

Authors: A A Badawy; M Evans
Journal: Biochem J Date: 1973-07 Impact factor: 3.857

10. The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase.

Authors: A A Badawy; M Evans
Journal: Biochem J Date: 1973-12 Impact factor: 3.857

8 in total

1. Regulation of hepatic haem metabolism. Disparate mechanisms of induction of haem oxygenase by drugs and metals.

Authors: B C Lincoln; J F Healey; H L Bonkovsky
Journal: Biochem J Date: 1988-02-15 Impact factor: 3.857

2. Evidence against involvement of cytochrome P-450 haem in the regulation of synthesis of mammalian liver 5-aminolaevulinate synthase.

Authors: A A Badawy
Journal: Biochem J Date: 1982-03-15 Impact factor: 3.857

3. Tryptophan and tryptophan pyrrolase in haem regulation. The role of lipolysis and direct displacement of serum-protein-bound tryptophan in the opposite effects of administration of endotoxin, morphine, palmitate, salicylate and theophylline on rat liver 5-aminolaevulinate synthase activity and the haem saturation of tryptophan pyrrolase.

Authors: A A Badawy; C J Morgan
Journal: Biochem J Date: 1982-09-15 Impact factor: 3.857

4. Tryptophan pyrrolase in haem regulation. The mechanisms of enhancement of rat liver 5-aminolaevulinate synthase activity by starvation and of the glucose effect on induction of the enzyme by 2-allyl-2-isopropylacetamide.

Authors: A A Badawy; A N Welch; C J Morgan
Journal: Biochem J Date: 1982-09-15 Impact factor: 3.857

5. Tryptophan pyrrolase in haem regulation. The mechanism of the opposite effects of tryptophan on rat liver 5-aminolaevulinate synthase activity and the haem saturation of tryptophan pyrrolase.

Authors: A A Badawy; A N Welch; C J Morgan
Journal: Biochem J Date: 1981-08-15 Impact factor: 3.857

6. Possible involvement of the enhanced tryptophan pyrrolase activity in the corticosterone- and starvation-induced increases in concentrations of nicotinamide-adenine dinucleotides (phosphates) in rat liver.

Authors: A A Badawy
Journal: Biochem J Date: 1981-04-15 Impact factor: 3.857

7. Tryptophan pyrrolase in haem regulation. Experiments with administered haematin and the relationship between the haem saturation of tryptophan pyrrolase and the activity of 5-aminolaevulinate synthase in rat liver.

Authors: A N Welch; A A Badawy
Journal: Biochem J Date: 1980-11-15 Impact factor: 3.857

8. Multiple roles of haem in cystathionine β-synthase activity: implications for hemin and other therapies of acute hepatic porphyria.

Authors: Abdulla A-B Badawy
Journal: Biosci Rep Date: 2021-07-30 Impact factor: 3.840