Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Activation and inactivation of phosphoenolpyruvate carboxykinase by ferrous ions.

Literature DB >> 7396825

Activation and inactivation of phosphoenolpyruvate carboxykinase by ferrous ions.

Abstract

Phosphoenolpyruvate carboxykinase from rat liver cytosol is activated by Fe2+ ions in either direction of catalysis. Preincubation of the purified enzyme with Fe2+ ions causes a time-dependent irreversible loss of activity; this is not seen with unpurified enzyme. Purified enzyme can be protected from inactivation by Fe2+ ions by partially purified protein fractions from liver (ferroactivator fractions). The possible role of ferroactivator and Fe2+ ions in regulating phosphoenolpyruvate carboxykinase is discussed.

Entities: Chemical Species

Mesh：

Substances：

Year: 1980 PMID： 7396825 PMCID： PMC1161372 DOI： 10.1042/bj1850451

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

12 in total

1. Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver.

Authors: F J Ballard; R W Hanson
Journal: Biochem J Date: 1967-09 Impact factor: 3.857

2. 3-Aminopicolinate: a synthetic metal-complexing activator of phosphoenolpyruvate carboxykinase.

Authors: M J MacDonald; H A Lardy
Journal: J Biol Chem Date: 1978-04-10 Impact factor: 5.157

3. Purification of phosphoenolpyruvate carboxykinase from the cytosol fraction of rat liver and the immunochemical demonstration of differences between this enzyme and the mitochondrial phosphoenolpyruvate carboxykinase.

Authors: F J Ballard; R W Hanson
Journal: J Biol Chem Date: 1969-10-25 Impact factor: 5.157

4. Response of phosphopyruvate carboxylase to tryptophan metabolites and metal ions.

Authors: R E Snoke; J B Johnston; H A Lardy
Journal: Eur J Biochem Date: 1971-12

5. P-enolpyruvate carboxykinase ferroactivator. Distribution, and the influence of diabetes and starvation.

Authors: M J MacDonald; L A Bentle; H A Lardy
Journal: J Biol Chem Date: 1978-01-10 Impact factor: 5.157

6. The activity of phosphoenolpyruvate carboxykinase in rat tissues. Assay techniques and effects of dietary and hormonal changes.

Authors: C I Pogson; S A Smith
Journal: Biochem J Date: 1975-11 Impact factor: 3.857

1. Identification of fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry.

Authors: D K Wong; B Y Lee; M A Horwitz; B W Gibson
Journal: Infect Immun Date: 1999-01 Impact factor: 3.441

2. [14C]bicarbonate fixation into glucose and other metabolites in the liver of the starved rat under halothane anaesthesia. Metabolic channelling of mitochondrial oxaloacetate.

Authors: D F Heath; J G Rose
Journal: Biochem J Date: 1985-05-01 Impact factor: 3.857

2 in total

Activation and inactivation of phosphoenolpyruvate carboxykinase by ferrous ions.

1. Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver.

2. 3-Aminopicolinate: a synthetic metal-complexing activator of phosphoenolpyruvate carboxykinase.

3. Purification of phosphoenolpyruvate carboxykinase from the cytosol fraction of rat liver and the immunochemical demonstration of differences between this enzyme and the mitochondrial phosphoenolpyruvate carboxykinase.

4. Response of phosphopyruvate carboxylase to tryptophan metabolites and metal ions.

5. P-enolpyruvate carboxykinase ferroactivator. Distribution, and the influence of diabetes and starvation.

6. The activity of phosphoenolpyruvate carboxykinase in rat tissues. Assay techniques and effects of dietary and hormonal changes.

7. P-enolpyruvate carboxykinase ferroactivator. Purification and some properties.

8. Interaction of anions and divalent metal ions with phosphoenolpyruvate carboxykinase.

9. A protein factor required for activation of phosphoenolpyruvate carboxykinase by ferrous ions.

10. The initial synthesis of proteins during development. Phosphoenolpyruvate carboxylase in rat liver at birth.

1. Identification of fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry.

2. [14C]bicarbonate fixation into glucose and other metabolites in the liver of the starved rat under halothane anaesthesia. Metabolic channelling of mitochondrial oxaloacetate.